ID   B8HMI3_CYAP4            Unreviewed;       792 AA.
AC   B8HMI3;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) {ECO:0000313|EMBL:ACL43598.1};
GN   OrderedLocusNames=Cyan7425_1219 {ECO:0000313|EMBL:ACL43598.1};
OS   Cyanothece sp. (strain PCC 7425 / ATCC 29141).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Gomontiellales; Cyanothecaceae;
OC   Cyanothece.
OX   NCBI_TaxID=395961 {ECO:0000313|EMBL:ACL43598.1};
RN   [1] {ECO:0000313|EMBL:ACL43598.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PCC 7425 {ECO:0000313|EMBL:ACL43598.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L.,
RA   Sato H., Zhao L., Sherman L., Pakrasi H., Richardson P.;
RT   "Complete sequence of chromosome Cyanothece sp. PCC 7425.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001344; ACL43598.1; -; Genomic_DNA.
DR   AlphaFoldDB; B8HMI3; -.
DR   STRING; 395961.Cyan7425_1219; -.
DR   KEGG; cyn:Cyan7425_1219; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_70_20_3; -.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
FT   DOMAIN          53..103
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          109..160
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          378..511
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          520..777
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   792 AA;  88964 MW;  F736D3AEA7613B42 CRC64;
     MSPVDSPDCK TLTHPIEPNR FPAAIPQWQS EARCEQIVAN NIAAIYRYLC SPDGSQGFVY
     ISAGCEEIYE IAADQIVQNA QLVWSLIHPE DRREFEEAMT AALICLTPWW NEHRLITPSG
     QLKWLRFSLQ PKLQADGTIV CDGMILDISD RKRQESERKQ AEQALMKRER YLSTLVEIQQ
     RLLALNSSEG NFYNHVLEPL GKAAEADRVY VFENSWNGQG QFCTSQKAEW CAAGIPAQID
     NPDLQNMPYA EFVPRWLTLL GQGGIVAGQV ADFPLQERVI LEPQGIVSLL VLPLFVHHQF
     FGFIGFDNCK QDRLWEPSDI DLLQAAAAAI SLSLERQQAN AQLVTVSLRD ALTSLPNRTL
     LFDRLEHALQ RYQRHPQQQF AVLFLDMDRF KSINDSLGHT AGDQVLLEMA HRLSQSVREE
     DTVARLGGDE FVILLEEVMN LQDALHCAQR IQDILAVPFE LNGTVVSLDA SIGVALADAR
     YHTPEELLRD ADIAMYEAKA AGRGGYQVFA PQMHEQAKLR LQKEQDLRLA LRKEQFQVVY
     QPIVNLLNHA LLGFEALIRW QHPQGVQIPV PEFLTIADQL GLLVKLEWWV LQTACEQLAQ
     WQSLPGLAGR PLSVSVNVSS TLFAQPNLVP EVARLIQQFK LPPQGLKLEI TEGVIGANAD
     VALENGQALQ SLGVQLHIDD FGTGYSSLKR LHQFPVHALK IDRSFVRHLD QSSENREIVR
     AIVSLANTLG IDVIAEGIET EQQCHYLQTL ACQQGQGYWF APPLTTAEVE QMLLQIQADH
     PWGLKPGFLP RS
//