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B8HM05

- SYL_CYAP4

UniProt

B8HM05 - SYL_CYAP4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Cyanothece sp. (strain PCC 7425 / ATCC 29141)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP395961:GJDE-2858-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Cyan7425_3031
    OrganismiCyanothece sp. (strain PCC 7425 / ATCC 29141)
    Taxonomic identifieri395961 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
    ProteomesiUP000002511: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 858858Leucine--tRNA ligasePRO_1000199190Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi395961.Cyan7425_3031.

    Structurei

    3D structure databases

    ProteinModelPortaliB8HM05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8HM05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESRYQPTAI EEKWQQTWAE VGIDQTPTDR SKPKFYALSM FPYPSGNLHM    50
    GHVRNYTITD VIARVRRMQG YRVLHPMGWD AFGLPAENAA IKRGIHPAKW 100
    TADNITQMRS ELKRLGLSYD WNCELATCSP DYYRWTQWIF LQFYQAGLAY 150
    QKEAAVNWDP IDQTVLANEQ VDSEGRSWRS GAKVERKLLR QWFLKITDYA 200
    EELLQDLDQL TGWPEKVRKL QANWIGKSTG AYLEFPIVGR DEKISVYTTR 250
    PDTVYGVSYV VLAPEHPLTL QVTTKKQLKA VKSFIQEVTA ASEIERTAED 300
    QPKRGIATGG KAINPFTGAE IPIWIADYVL YEYGTGAVMG VPAHDSRDFK 350
    FAQTYQLPIR QVIIPPDPDL NEQPILQEAY TEPGLLINSG EFDGMPSTDA 400
    KAAIVAKAEA TGWGQARVQY RLRDWLISRQ RYWGAPIPVI HCPQCGIVPV 450
    PEADLPVVLP DDVQFSGRGP SPLAQLESWV KVNCPTCNTP ARRETDTMDT 500
    FIDSSWYYLR YPDAQNDQQV FDPAKTNDWL PVDQYVGGIE HAILHLLYSR 550
    FFTKVLRDRG LLNFDEPFQR LLTQGMVQGL TYTNPNRSDS SRYIPSNLVD 600
    PNDPKDPETG EPLEVSYQTM SKSKYNGVAP EEVINKYGAD TARMFILFKA 650
    PPEKDLEWDD ADVEGQFRFL NRVWRLVTQY PVIEPTTKQG DALAKEEKEL 700
    RRAIHTAIKE ITADLGEEYQ LNTAVSELMK LSNALTDASC KDSVIYTEGI 750
    ETLLLLLAPF APHISEELWQ QLGHTTSVHQ QSWPQVDPSA LIVDEITIVI 800
    QILGKTRGTI QVPASSSREE LEEYARQTPV AQRYLEGKTI KKVIVVPGKL 850
    VNFVVADA 858
    Length:858
    Mass (Da):97,261
    Last modified:March 3, 2009 - v1
    Checksum:i0DAA53022B113E82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001344 Genomic DNA. Translation: ACL45365.1.
    RefSeqiWP_012628431.1. NC_011884.1.
    YP_002483726.1. NC_011884.1.

    Genome annotation databases

    EnsemblBacteriaiACL45365; ACL45365; Cyan7425_3031.
    GeneIDi7288964.
    KEGGicyn:Cyan7425_3031.
    PATRICi21567025. VBICyaSp30657_3020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001344 Genomic DNA. Translation: ACL45365.1 .
    RefSeqi WP_012628431.1. NC_011884.1.
    YP_002483726.1. NC_011884.1.

    3D structure databases

    ProteinModelPortali B8HM05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 395961.Cyan7425_3031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL45365 ; ACL45365 ; Cyan7425_3031 .
    GeneIDi 7288964.
    KEGGi cyn:Cyan7425_3031.
    PATRICi 21567025. VBICyaSp30657_3020.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CSP395961:GJDE-2858-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
      Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
      MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7425 / ATCC 29141.

    Entry informationi

    Entry nameiSYL_CYAP4
    AccessioniPrimary (citable) accession number: B8HM05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3