B8HK58 (B8HK58_CYAP4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388
EC=3.5.1.- HAMAP MF_00388

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase HAMAP MF_00388

Gene names

Name:	lpxC HAMAP MF_00388
Ordered Locus Names:	Cyan7425_4498

Organism

Cyanothece sp. (strain PCC 7425 / ATCC 29141) [Complete proteome] [HAMAP] EMBL ACL46808.1

Taxonomic identifier

395961 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the LpxC family. HAMAP MF_00388

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00388 Lipid synthesis
Molecular function	Hydrolase HAMAP MF_00388
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8HK58 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 055574523178CAF0	FASTA	299	32,737
	10 20 30 40 50 60 MSGDVSLSLP PGLAAYLRSP WQHTLQRSFV CTGVGLHSGQ SAQVRVLPAE PDRGRYFCRL 70 80 90 100 110 120 DFNTEDSPII PAQLQSVRQT LLSTELVAGK VGVRTVEHLL AALAGLGIDN ARIEIDGAEV 130 140 150 160 170 180 PLLDGSAQEW VAAIVQAGWQ QQTRLRPRWH LKHPVSVQQE DGFAIALPAV DTRFSYGIEF 190 200 210 220 230 240 SSHPVIGRQW CSFTLEEFAQ EIAPARTFGF AEQVEQLRAR GLIKGGTLEN ALVCSPEGWL 250 260 270 280 290 NPPLRFADEP VRHKLLDLIG DLSLLGTLPP AHYLAYKGSH ALHSQLAAQI EGVREPLLV

References

[1]

"Complete sequence of chromosome Cyanothece sp. PCC 7425." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L., Sato H., Zhao L., Sherman L., Pakrasi H.B., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7425 / ATCC 29141.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001344 Genomic DNA. Translation: ACL46808.1.
RefSeq	YP_002485169.1. NC_011884.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8HK58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7290451.
GenomeReviews	Gene locus Cyan7425_4498 in contig CP001344_GR.
KEGG	cyn:Cyan7425_4498.
PATRIC	21569997. VBICyaSp30657_4488.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	B8HK58.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8HK58_CYAP4

Accession

Primary (citable) accession number: B8HK58

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)