Skip Header

Contribute Send feedback
Read comments (?) or add your own

B8HK28 (B8HK28_CYAP4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405
Gene names
Ordered Locus Names:Cyan7425_4468
OrganismCyanothece sp. (strain PCC 7425 / ATCC 29141) [Complete proteome] [HAMAP] EMBL ACL46778.1
Taxonomic identifier395961 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Cyanothece

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. HAMAP MF_01405 SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP MF_01405

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP MF_01405
Region67 – 682Substrate binding By similarity HAMAP MF_01405

Sites

Metal binding381Magnesium or manganese By similarity HAMAP MF_01405
Metal binding671Magnesium or manganese By similarity HAMAP MF_01405
Binding site1491Substrate By similarity HAMAP MF_01405
Binding site1691Substrate By similarity HAMAP MF_01405
Binding site1751Substrate By similarity HAMAP MF_01405

Sequences

Sequence LengthMass (Da)Tools
B8HK28 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 1F7EC31E55DC4170

FASTA19321,044
        10         20         30         40         50         60 
MPILVVASHN PGKVKEFQTY FQDLPWQLIL MPADLEIEET GETFADNACL KASTVARLTG 

        70         80         90        100        110        120 
NWAIADDSGL EVAALNGQPG VYSARYGATD PDRIQRLLTE LGQEPNRTAR FVCAIAVARP 

       130        140        150        160        170        180 
TGEIALQTEG VCPGEILSTP QGEGGFGYDP IFYVPEKQMT FAQMPSTVKQ QISHRGRALR 

       190 
SLLPQLSLLL NRA

« Hide

References

[1]"Complete sequence of chromosome Cyanothece sp. PCC 7425."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L., Sato H., Zhao L., Sherman L., Pakrasi H.B., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7425 / ATCC 29141.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001344 Genomic DNA. Translation: ACL46778.1.
RefSeqYP_002485139.1. NC_011884.1.

3D structure databases

ProteinModelPortalB8HK28.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8HK28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7290421.
GenomeReviewsGene locus Cyan7425_4468 in contig CP001344_GR.
KEGGcyn:Cyan7425_4468.
PATRIC21569933. VBICyaSp30657_4456.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697237.
OMAGVYTADW.
PhylomeDBB8HK28.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8HK28_CYAP4
AccessionPrimary (citable) accession number: B8HK28
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info