B8HGQ6 (B8HGQ6_ARTCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Catalase-peroxidase HAMAP MF_01961
Short name=CP HAMAP MF_01961
EC=1.11.1.21 HAMAP MF_01961

Alternative name(s):
Peroxidase/catalase HAMAP MF_01961

Gene names

Name:	katG HAMAP MF_01961
Ordered Locus Names:	Achl_3365

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	768 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	2 H2O2 = O2 + 2 H2O. HAMAP MF_01961 RuleBase RU003451 SAAS SAAS019794 Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 SAAS SAAS019794
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity. HAMAP MF_01961 SAAS SAAS019794
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily. HAMAP MF_01961 RuleBase RU003451

Ontologies

Keywords
Biological process	Hydrogen peroxide HAMAP MF_01961 RuleBase RU003451 SAAS SAAS019794
Ligand	Heme HAMAP MF_01961 RuleBase RU003900 SAAS SAAS000763 Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: HAMAP heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	136	1	Proton acceptor By similarity HAMAP MF_01961
	Metal binding	298	1	Iron (heme axial ligand) By similarity HAMAP MF_01961
	Site	132	1	Transition state stabilizer By similarity HAMAP MF_01961
Amino acid modifications
	Cross-link	135 ↔ 257		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-283) By similarity HAMAP MF_01961
	Cross-link	257 ↔ 283		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-135) By similarity HAMAP MF_01961

Sequences

	Sequence		Length	Mass (Da)
	B8HGQ6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 240D7845D6391B2A	FASTA	768	83,574
	10 20 30 40 50 60 MTDPQEHPPL PASGSAQGAG HAAGQNAEGG CPVVHGGATA QGSESENPAI DAPQPKGHRP 70 80 90 100 110 120 RTIADWWPNQ LDLSVLHANH PAGNPLGPDF SYRNEFQKLD VEALKQDITE VLTTSQDWWP 130 140 150 160 170 180 ADFGHYGGLM IRMSWHAAGT YRVHDGRGGA GDGGQRFAPL NSWPDNANLD KARRLLWPVK 190 200 210 220 230 240 QKYGQKLSWA DLLVLAGNVA LESMGFKTFG FAFGREDVWE PEEIFWGPED AWLGDERYVA 250 260 270 280 290 300 EGQMADEVGA TEMGLIYVNP EGPMGNPDPL AAAAFIRETF KRMAMNDEET VALIAGGHTF 310 320 330 340 350 360 GKTHGAGSAD DHVGPEPEGA DLESQGLGWL STYGSGKGAD TITSGLEVTW TDVPTQWSNR 370 380 390 400 410 420 FFEILFGHEW ELVESPAGAK QWVAKDAEKI IPDAHDPEKK HRPTMLTTDL SLRVDPEYEK 430 440 450 460 470 480 ISRRFLENPD QFALAFAKAW YKLLHRDMGP VGPHLLGPWV PEAQLWQDPV PAVDHDLIGE 490 500 510 520 530 540 ADITDLKAKL LDSGLTVQQL AGTAWASAAT YRKTDRRGGA NGARIRLEPQ RSWEANEPEQ 550 560 570 580 590 600 LATVLQTLER VQEEFNAGQG NGKKVSLADL IVLGGAAAVE KAASDAGVPV TVPFRPGRTD 610 620 630 640 650 660 AAQEQTDVES FGYLQPRADG FRNYIRPGVK LQPETLLLDK AYLLDLSAPE MTALVGGMRA 670 680 690 700 710 720 LGTNVGGSGH GVLTDKPQAL TNDFFVNLLS PGTKWKASEN EENVYEITDV ATGEVKWTAT 730 740 750 760 AVDLVFGSNS QLRALAEVYA SGDAKEKFVH DFVAAWAKVM ELDRFDLN

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL41322.1.
RefSeq	YP_002489411.1. NC_011886.1.
3D structure databases
ProteinModelPortal	B8HGQ6.
SMR	B8HGQ6. Positions 65-767.
ModBase	Search...
Protein-protein interaction databases
STRING	B8HGQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7294846.
GenomeReviews	Gene locus Achl_3365 in contig CP001341_GR.
KEGG	ach:Achl_3365.
PATRIC	20993363. VBIArtChl38304_4044.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285610.
OMA	KRHAPSM.
ProtClustDB	PRK15061.
Family and domain databases
HAMAP	MF_01961. Catal_peroxid. [Tree]
InterPro	IPR000763. Catalase_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
TIGRFAMs	TIGR00198. Cat_per_HPI. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8HGQ6_ARTCA

Accession

Primary (citable) accession number: B8HGQ6

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)