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B8HGC9

- ASSY_ARTCA

UniProt

B8HGC9 - ASSY_ARTCA

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Protein

Argininosuccinate synthase

Gene
argG, Achl_1503
Organism
Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Citrulline By similarity
Binding sitei117 – 1171ATP; via amide nitrogen By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei175 – 1751Citrulline By similarity
Binding sitei259 – 2591Citrulline By similarity
Binding sitei271 – 2711Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACHL452863:GH1A-1529-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Achl_1503
OrganismiArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000002505: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthaseUniRule annotationPRO_1000191876Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi452863.Achl_1503.

Structurei

3D structure databases

ProteinModelPortaliB8HGC9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8HGC9-1 [UniParc]FASTAAdd to Basket

« Hide

MTERIVLAYS GGLDTSVAIG WIGEATGAEV IAVAVDVGQG GESLETIRQR    50
ALGCGAVEAY VADARDEFAN EYAMPTLKAN ALYQGHYPLV SAISRPVIVK 100
HLVKAAREFG ATTVAHGCTG KGNDQVRFEV GIQTLGPDLK CIAPVRDLAL 150
TRDKAIAFAE EKGLPIETTK KNPYSIDQNV WGRAVETGYL EDIWNAPTKD 200
IYDYTATPEF PPAPDEVTIS FQAGVPVAID GVKVSPLQAI QELNRRAGAQ 250
GVGRIDVVED RLVGIKSREI YEAPGAMALI TAHKHLEDIT IEREQARFKA 300
TVGQRWAELV YDGQWFSPLK RSLDAFIEDT QKYVSGDIRM VLHGGQAIVN 350
GRRSDTSLYD FDLATYDTGD TFDQSMARGF IELWGMSSKV ASGRDLRVEG 400
K 401
Length:401
Mass (Da):43,685
Last modified:March 3, 2009 - v1
Checksum:i4753B68C4FA2BB47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001341 Genomic DNA. Translation: ACL39491.1.
RefSeqiYP_002487580.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL39491; ACL39491; Achl_1503.
GeneIDi7292952.
KEGGiach:Achl_1503.
PATRICi20989549. VBIArtChl38304_2169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001341 Genomic DNA. Translation: ACL39491.1 .
RefSeqi YP_002487580.1. NC_011886.1.

3D structure databases

ProteinModelPortali B8HGC9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452863.Achl_1503.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL39491 ; ACL39491 ; Achl_1503 .
GeneIDi 7292952.
KEGGi ach:Achl_1503.
PATRICi 20989549. VBIArtChl38304_2169.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci ACHL452863:GH1A-1529-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Entry informationi

Entry nameiASSY_ARTCA
AccessioniPrimary (citable) accession number: B8HGC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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