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Protein

Argininosuccinate synthase

Gene

argG

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87Citrulline1
Binding sitei117ATP; via amide nitrogen1
Binding sitei119Aspartate1
Binding sitei123Aspartate1
Binding sitei123Citrulline1
Binding sitei124Aspartate1
Binding sitei127Citrulline1
Binding sitei175Citrulline1
Binding sitei259Citrulline1
Binding sitei271Citrulline1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATP9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:Achl_1503
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001918761 – 401Argininosuccinate synthaseAdd BLAST401

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi452863.Achl_1503.

Structurei

3D structure databases

ProteinModelPortaliB8HGC9.
SMRiB8HGC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Phylogenomic databases

eggNOGiENOG4105CDH. Bacteria.
COG0137. LUCA.
HOGENOMiHOG000230093.
KOiK01940.
OMAiGVGRIDM.
OrthoDBiPOG091H01U0.

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR11587. PTHR11587. 1 hit.
PfamiView protein in Pfam
PF00764. Arginosuc_synth. 1 hit.
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiView protein in PROSITE
PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B8HGC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERIVLAYS GGLDTSVAIG WIGEATGAEV IAVAVDVGQG GESLETIRQR
60 70 80 90 100
ALGCGAVEAY VADARDEFAN EYAMPTLKAN ALYQGHYPLV SAISRPVIVK
110 120 130 140 150
HLVKAAREFG ATTVAHGCTG KGNDQVRFEV GIQTLGPDLK CIAPVRDLAL
160 170 180 190 200
TRDKAIAFAE EKGLPIETTK KNPYSIDQNV WGRAVETGYL EDIWNAPTKD
210 220 230 240 250
IYDYTATPEF PPAPDEVTIS FQAGVPVAID GVKVSPLQAI QELNRRAGAQ
260 270 280 290 300
GVGRIDVVED RLVGIKSREI YEAPGAMALI TAHKHLEDIT IEREQARFKA
310 320 330 340 350
TVGQRWAELV YDGQWFSPLK RSLDAFIEDT QKYVSGDIRM VLHGGQAIVN
360 370 380 390 400
GRRSDTSLYD FDLATYDTGD TFDQSMARGF IELWGMSSKV ASGRDLRVEG

K
Length:401
Mass (Da):43,685
Last modified:March 3, 2009 - v1
Checksum:i4753B68C4FA2BB47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL39491.1.
RefSeqiWP_015936712.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL39491; ACL39491; Achl_1503.
KEGGiach:Achl_1503.

Similar proteinsi

Entry informationi

Entry nameiASSY_PSECP
AccessioniPrimary (citable) accession number: B8HGC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families