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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi519MagnesiumUniRule annotation1
Metal bindingi525MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Achl_1439
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857181 – 752Polyribonucleotide nucleotidyltransferaseAdd BLAST752

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_1439.

Structurei

3D structure databases

ProteinModelPortaliB8HG67.
SMRiB8HG67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini585 – 644KHUniRule annotationAdd BLAST60
Domaini656 – 728S1 motifUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR014069. GPSI/PNP.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

B8HG67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPEIQFSE AVIDNGRFGK RVIRFETGRL AKQAAGAAMV YIDEDTALLS
60 70 80 90 100
ATTAGKHPRE GFDFFPLTVD VEERMYAAGR IPGSFFRREG RPSTEAILAC
110 120 130 140 150
RLMDRPLRPA FVKGLRNEVQ IVVTVLAINP DELYDVVAIN ASSMSTQLSG
160 170 180 190 200
LPFSGPIGGV RVALVADENG SQWVAFPKHS QLENSVFNMV VAGRVAGDDV
210 220 230 240 250
AIMMVEAEAT DNSWNLIKEQ GATAPTEEVV SEGLEAAKPF IKALCDAQAD
260 270 280 290 300
LAARAAKPTV EFPVFLDYQD DVYAAVEAAA ADKLAAVFQI ADKQERDTAS
310 320 330 340 350
DALKDEVTSS LAGQFEGREK ELSAAFRSVT KHVVRQRILK DQIRIDGRGL
360 370 380 390 400
TDIRQLTAEV EVLPRVHGSA IFERGETQIM GVTTLNMLKM EQQIDSLSPV
410 420 430 440 450
TRKRYMHNYN FPPYSTGETG RVGSPKRREI GHGALAERAL VPVLPSREEF
460 470 480 490 500
PYAIRQVSEA LGSNGSTSMG SVCASTLSML NAGVPLKAAV AGIAMGLVSD
510 520 530 540 550
QVDGQTRYAA LTDILGAEDA FGDMDFKVAG TSEFVTAIQL DTKLDGIPAS
560 570 580 590 600
VLAAALKQAR EARLHILEVI NSAIDTPDEL SEFAPRVIAV KIPVDKIGEV
610 620 630 640 650
IGPKGKMINQ IQEDTGADIS IEDDGTVYIG ATNGPSADAA RSAINAIANP
660 670 680 690 700
QVPEIGERYL GTVVKTTTFG AFVSLTPGKD GLLHISELRK LANGKRVDNV
710 720 730 740 750
DDVVSVGQKV QVEITKIDDR GKLSLSPVVA EEEGAEGAER AHATEPAEGA

EI
Length:752
Mass (Da):80,574
Last modified:March 3, 2009 - v1
Checksum:i588C18EAA6EE4AD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL39429.1.
RefSeqiWP_015936652.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL39429; ACL39429; Achl_1439.
GeneIDi32446710.
KEGGiach:Achl_1439.

Similar proteinsi

Entry informationi

Entry nameiPNP_PSECP
AccessioniPrimary (citable) accession number: B8HG67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families