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B8HFX6 (B8HFX6_ARTCA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uricase RuleBase RU004455 PIRNR PIRNR000241
EC=1.7.3.3 RuleBase RU004455 PIRNR PIRNR000241
Alternative name(s):
Urate oxidase PIRNR PIRNR000241
Gene names
Ordered Locus Names:Achl_3208
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin By similarity. RuleBase RU004455 PIRNR PIRNR000241

Catalytic activity

Urate + O2 + H2O = 5-hydroxyisourate + H2O2. RuleBase RU004455 PIRNR PIRNR000241

Pathway

Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. PIRNR PIRNR000241

Sequence similarities

Belongs to the uricase family. RuleBase RU004455 PIRNR PIRNR000241

Ontologies

Keywords
   Biological processPurine metabolism RuleBase RU004455 PIRNR PIRNR000241
   Molecular functionOxidoreductase RuleBase RU004455 PIRNR PIRNR000241 EMBL ACL41169.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine base metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionurate oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region222 – 2232Substrate binding By similarity PIRSR PIRSR000241-2

Sites

Active site1761Charge relay system By similarity PIRSR PIRSR000241-1
Active site2231Charge relay system By similarity PIRSR PIRSR000241-1
Binding site1761Substrate By similarity PIRSR PIRSR000241-2

Sequences

Sequence LengthMass (Da)Tools
B8HFX6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C1C3526689D44260

FASTA30233,712
        10         20         30         40         50         60 
MSSKIILGEN QYGKAEVRVV KITRDTNRHE IEDLNVTSQL RGDFSAAHLE GDNAHVVATD 

        70         80         90        100        110        120 
TQKNTIYAFA RDGIGSPEAF LLRLGEHFTS SFDWVSGGRW EAESYAWNRI QAHGSEHDHS 

       130        140        150        160        170        180 
FVRNGQEVRT AVLVRDGATS HLISGLKDLT VLKSTESGFV GYPRDRYTTL PETTDRILAT 

       190        200        210        220        230        240 
DVSARWRFKT GTDFSTLDFN KSYEDVKGLL LEGFTEKYSH ALQQTLFDMG TKVLEAHSEI 

       250        260        270        280        290        300 
DEIKFSMPNK HHFLVDLSPF GLDNPNEVFF AADRPYGLIE ATVQRDDATA APAAWSGIAG 


FC

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References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001341 Genomic DNA. Translation: ACL41169.1.
RefSeqYP_002489258.1. NC_011886.1.

3D structure databases

ProteinModelPortalB8HFX6.
SMRB8HFX6. Positions 3-296.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8HFX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7294689.
GenomeReviewsGene locus Achl_3208 in contig CP001341_GR.
KEGGach:Achl_3208.
PATRIC20993053. VBIArtChl38304_3889.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG558657.
OMAHDHSFVR.
ProtClustDBCLSK881003.

Family and domain databases

InterProIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
Gene3DG3DSA:3.10.270.10. Uricase. 1 hit.
KOK00365.
PANTHERPTHR10395:SF1. Uricase. 1 hit.
PfamPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFPIRSF000241. Urate_oxidase. 1 hit.
PRINTSPR00093. URICASE.
TIGRFAMsTIGR03383. Urate_oxi. 1 hit.
PROSITEPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8HFX6_ARTCA
AccessionPrimary (citable) accession number: B8HFX6
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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