B8HFT6 (B8HFT6_ARTCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	Achl_3168

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ACL41129.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	541	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	634	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	B8HFT6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 053CD670275A6CB6	FASTA	670	72,939
	10 20 30 40 50 60 MSQDTPSSTA TVPAAPAGQG AQQGDAFENL LHETRTFPPT PEFAANAVVK AGEYAEADAD 70 80 90 100 110 120 RPAFWAKQAR ELLTWSKDFD EALDWSNPPF AKWFVGGEVN AAYNALDRHV ENGLGDRVAI 130 140 150 160 170 180 HFEGEPGDSR SYTYAELTEE VKKAANAFES LGVSKGDRVA VYLPMIPEAV ITLLACARIG 190 200 210 220 230 240 AVHSVVFGGF SADALRSRID DAEAKLVVTA DGTYRRGKPS ALKPAVDDAL SQDGHTVQNV 250 260 270 280 290 300 VVVKRNGQDV DWHEGRDHWW DETVGEASAE HTAVGHDSEH PLFILYTSGT TGKPKGILHT 310 320 330 340 350 360 TGGYLTQTAY THKAVFDLHP ETDVYWCTAD VGWVTGHSYV TYAPLINGAT QVMYEGTPDS 370 380 390 400 410 420 PHQGRWWEIV EKYKVSILYT APTAIRTFMK WGRDIPDKYD LSSIRVLGSV GEPINPEAWM 430 440 450 460 470 480 WYRTVIGGDN APIVDTWWQT ETGAQMIAPL PGVTAAKPGS AQVPLPGIAV DVVDEMGESV 490 500 510 520 530 540 PDGHGGFLVI REPWPAMLRG IWGDPERFKD TYWSRFETMY FAGDGAKKDE DGDIWLLGRV 550 560 570 580 590 600 DDVMNVSGHR LSTTEIESAL VSHPAVAEAA VVGASDETTG QAVVAFVILR GDAANNGDET 610 620 630 640 650 660 VQELRNHVGK EIGPIAKPKN ILVVPELPKT RSGKIMRRLL KDVAEGRDPG DATTLADPTI 670 MQQIAQSLRK

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL41129.1.
RefSeq	YP_002489218.1. NC_011886.1.
3D structure databases
ProteinModelPortal	B8HFT6.
ModBase	Search...
Protein-protein interaction databases
STRING	B8HFT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7294648.
GenomeReviews	Gene locus Achl_3168 in contig CP001341_GR.
KEGG	ach:Achl_3168.
PATRIC	20992971. VBIArtChl38304_3849.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	HEERIHA.
ProtClustDB	CLSK779889.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8HFT6_ARTCA

Accession

Primary (citable) accession number: B8HFT6

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)