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B8HF09

- ISPE_ARTCA

UniProt

B8HF09 - ISPE_ARTCA

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Protein
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Gene
ispE, Achl_1284
Organism
Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity.UniRule annotation

Catalytic activityi

ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei20 – 201 By similarity
Active sitei154 – 1541 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi112 – 12211ATP Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACHL452863:GH1A-1307-MONOMER.
UniPathwayiUPA00056; UER00094.

Names & Taxonomyi

Protein namesi
Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (EC:2.7.1.148)
Short name:
CMK
Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene namesi
Name:ispE
Ordered Locus Names:Achl_1284
OrganismiArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000002505: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3203204-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation
PRO_1000117876Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_1284.

Structurei

3D structure databases

ProteinModelPortaliB8HF09.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1947.
HOGENOMiHOG000019600.
KOiK00919.
OMAiEGYHPIS.
OrthoDBiEOG62VNQ2.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00061. IspE.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF010376. IspE. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00154. ispE. 1 hit.

Sequencei

Sequence statusi: Complete.

B8HF09-1 [UniParc]FASTAAdd to Basket

« Hide

MNTPAVRFAA RTVRVKAPGK INVSLDVGPR RPDGYHSVAS VYLAVSLYEE    50
VAATSTETPG ITVSLSPDST LDLDAVDIPL DASNLAYRAA AIMADVSEHA 100
TGVHLEITKR VPVAGGMGGG SADAAATLLA CDALWNSGLS REELAHLAAE 150
LGADVPFSLL GGTAVGLGVG DQLSPALAKA KTHWVLVTAD FGLSTPEVFR 200
TLDRLREAEG VDADEPTGVD PNILAALRGG DADALSRILV NDLQRASIEL 250
APSLRDTLGI GESHGAIAGI VSGSGPTVAL LADDSVAAEA LAEDLQHQGL 300
SALAVHGPVP GARIISDTLL 320
Length:320
Mass (Da):32,634
Last modified:March 3, 2009 - v1
Checksum:iDE557EC170B2EE35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001341 Genomic DNA. Translation: ACL39275.1.
RefSeqiYP_002487364.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL39275; ACL39275; Achl_1284.
GeneIDi7292730.
KEGGiach:Achl_1284.
PATRICi20989089. VBIArtChl38304_1942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001341 Genomic DNA. Translation: ACL39275.1 .
RefSeqi YP_002487364.1. NC_011886.1.

3D structure databases

ProteinModelPortali B8HF09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452863.Achl_1284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL39275 ; ACL39275 ; Achl_1284 .
GeneIDi 7292730.
KEGGi ach:Achl_1284.
PATRICi 20989089. VBIArtChl38304_1942.

Phylogenomic databases

eggNOGi COG1947.
HOGENOMi HOG000019600.
KOi K00919.
OMAi EGYHPIS.
OrthoDBi EOG62VNQ2.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00094 .
BioCyci ACHL452863:GH1A-1307-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00061. IspE.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR004424. IspE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF010376. IspE. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00154. ispE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Entry informationi

Entry nameiISPE_ARTCA
AccessioniPrimary (citable) accession number: B8HF09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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