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B8HCG9 (ACPS_ARTCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holo-[acyl-carrier-protein] synthase

Short name=Holo-ACP synthase
EC=2.7.8.7
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene names
Name:acpS
Ordered Locus Names:Achl_2620
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP-Rule MF_00101

Catalytic activity

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP-Rule MF_00101

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00101

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00101.

Sequence similarities

Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

macromolecule biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionholo-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 115115Holo-[acyl-carrier-protein] synthase HAMAP-Rule MF_00101
PRO_1000118789

Sites

Metal binding81Magnesium By similarity
Metal binding501Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
B8HCG9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: BBEA870E7884A822

FASTA11512,326
        10         20         30         40         50         60 
MIVGIGVDVV DIERFGRQLE RTPGLRDRLF VPAERELNTR SLAARFAAKE AVAKVLGAPA 

        70         80         90        100        110 
GMNWQDCWIG LDHNGPTVQV KGTVLAVAEA KGVKRWHLSI SHDGGIATAT VLAEG 

« Hide

References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001341 Genomic DNA. Translation: ACL40585.1.
RefSeqYP_002488674.1. NC_011886.1.

3D structure databases

ProteinModelPortalB8HCG9.
SMRB8HCG9. Positions 1-115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING452863.Achl_2620.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL40585; ACL40585; Achl_2620.
GeneID7294096.
KEGGach:Achl_2620.
PATRIC20991875. VBIArtChl38304_3305.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG274589.
HOGENOMHOG000014315.
KOK00997.
OMAAPAGMNW.
OrthoDBEOG6W7266.
ProtClustDBPRK00070.

Enzyme and pathway databases

BioCycACHL452863:GH1A-2673-MONOMER.

Family and domain databases

Gene3D3.90.470.20. 1 hit.
HAMAPMF_00101. AcpS.
InterProIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view]
PfamPF01648. ACPS. 1 hit.
[Graphical view]
ProDomPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56214. SSF56214. 1 hit.
TIGRFAMsTIGR00556. pantethn_trn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACPS_ARTCA
AccessionPrimary (citable) accession number: B8HCG9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families