B8HCF9 (B8HCF9_ARTCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Achl_2610

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ACL40575.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B8HCF9 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: A9DDD5C2D80ABC38	FASTA	558	58,561
	10 20 30 40 50 60 MTGVPSDLEI ARAARIRPIE DIAAAAGVNA AALEQYGRYK AKIDPARLDA PPPHGKLVLV 70 80 90 100 110 120 SAMSPTPAGE GKSTTTVGLA DSLARAGHNV MIALREPSLG PVLGMKGGAT GGGYSQVLPM 130 140 150 160 170 180 DEINLHFTGD FHAITSANNA LMALVDNHIY QGNALNIDPR RMTFKRVLDM NDRALREVVI 190 200 210 220 230 240 GLGGPAQGVP RQDGFDITVA SEIMAVFCLA TDLADLRERL GRITFGYTYE RVPVTVADLG 250 260 270 280 290 300 VQGALALLLK EAVKPNLVQT IAGTPALVHG GPFANIAHGC NSLIATQTAR RLADIVVTEA 310 320 330 340 350 360 GFGADLGAEK FMDIKARIGG LAPSAVVVVA TVRALKMQGG VAKDQLTRPD MAALEAGVEN 370 380 390 400 410 420 LRRHVHNVEK FGVTPVVAIN RFATDTAEEL DWLLAWCAAE GVPAAVADVW GRGGGGDGGD 430 440 450 460 470 480 ELAALVARAL DAPGRFRHLY PLELSVEDKI RTIAQEIYGA DGVDFSVPAL KRLADIERNG 490 500 510 520 530 540 WGGLPVCMAK TQYSFTDDAT RLGAPKGFTI HVRDLLPKTG AGFIVALTGA VMTMPGLPAV 550 PAALRMDVDP DGNPVGLT

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL40575.1.
RefSeq	YP_002488664.1. NC_011886.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8HCF9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7294086.
GenomeReviews	Gene locus Achl_2610 in contig CP001341_GR.
KEGG	ach:Achl_2610.
PATRIC	20991859. VBIArtChl38304_3297.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8HCF9_ARTCA

Accession

Primary (citable) accession number: B8HCF9

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)