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Protein

Alanine racemase

Gene

Achl_2606

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Achl_2606)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei176SubstrateUniRule annotation1
Active sitei309Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei356Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciACHL452863:GH1A-2622-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Achl_2606Imported
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)Imported
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_2606

Structurei

3D structure databases

ProteinModelPortaliB8HCF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 417Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.102 hits
3.20.20.101 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

B8HCF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLNPPGTLR RRTSDYSAAG TPTRITSVTY PAPTGEISAA SVHDPHYERS
60 70 80 90 100
AVIDLDAIRH NVRRLAAAAS PAKVMAVVKA DAYGHGAVPV ARAALEAGAS
110 120 130 140 150
WLGVAHISEA LALRAAGIDA PLLAWLHTTD SNFGAAVAAG VDIGCSGWEL
160 170 180 190 200
ERIVAAAREQ ERPARIHLKV DTGLGRNGAT LEYWDTLVGE AMEYQDQGLL
210 220 230 240 250
RVVGIFSHLA VADEPERPET DHQLAAFRDA LAVAEDAGVD AEVRHLANTP
260 270 280 290 300
ATLSRPDTHF DLVRVGLGIY GLSPFDGQTS AELGLRPAMA LRTKVSQCKV
310 320 330 340 350
VPAGQGVSYG LHYRTAAAST LGLIPLGYAD GIPRVATGGP VRVAGTTYPV
360 370 380 390 400
VGRIAMDQMV IDLGQGVQGA ALLGAEAELF GSGADGGPTA DDWARAAGTI
410 420 430
NYEIVTRISP RVPRRFINEQ DTSGGGDASA AGSEGAL
Length:437
Mass (Da):45,478
Last modified:March 3, 2009 - v1
Checksum:i4B03F58808E65CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA Translation: ACL40571.1

Genome annotation databases

EnsemblBacteriaiACL40571; ACL40571; Achl_2606
KEGGiach:Achl_2606

Similar proteinsi

Entry informationi

Entry nameiB8HCF5_PSECP
AccessioniPrimary (citable) accession number: B8HCF5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported