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B8HCF5

- B8HCF5_ARTCA

UniProt

B8HCF5 - B8HCF5_ARTCA

Protein

Alanine racemase

Gene

Achl_2606

Organism
Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation
    Active sitei309 – 3091Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei356 – 3561Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciACHL452863:GH1A-2659-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Achl_2606Imported
    OrganismiArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)Imported
    Taxonomic identifieri452863 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
    ProteomesiUP000002505: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi452863.Achl_2606.

    Structurei

    3D structure databases

    ProteinModelPortaliB8HCF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiIYSHLAL.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8HCF5-1 [UniParc]FASTAAdd to Basket

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    MPLNPPGTLR RRTSDYSAAG TPTRITSVTY PAPTGEISAA SVHDPHYERS    50
    AVIDLDAIRH NVRRLAAAAS PAKVMAVVKA DAYGHGAVPV ARAALEAGAS 100
    WLGVAHISEA LALRAAGIDA PLLAWLHTTD SNFGAAVAAG VDIGCSGWEL 150
    ERIVAAAREQ ERPARIHLKV DTGLGRNGAT LEYWDTLVGE AMEYQDQGLL 200
    RVVGIFSHLA VADEPERPET DHQLAAFRDA LAVAEDAGVD AEVRHLANTP 250
    ATLSRPDTHF DLVRVGLGIY GLSPFDGQTS AELGLRPAMA LRTKVSQCKV 300
    VPAGQGVSYG LHYRTAAAST LGLIPLGYAD GIPRVATGGP VRVAGTTYPV 350
    VGRIAMDQMV IDLGQGVQGA ALLGAEAELF GSGADGGPTA DDWARAAGTI 400
    NYEIVTRISP RVPRRFINEQ DTSGGGDASA AGSEGAL 437
    Length:437
    Mass (Da):45,478
    Last modified:March 3, 2009 - v1
    Checksum:i4B03F58808E65CB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001341 Genomic DNA. Translation: ACL40571.1.
    RefSeqiWP_015937781.1. NC_011886.1.
    YP_002488660.1. NC_011886.1.

    Genome annotation databases

    EnsemblBacteriaiACL40571; ACL40571; Achl_2606.
    GeneIDi7294082.
    KEGGiach:Achl_2606.
    PATRICi20991851. VBIArtChl38304_3293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001341 Genomic DNA. Translation: ACL40571.1 .
    RefSeqi WP_015937781.1. NC_011886.1.
    YP_002488660.1. NC_011886.1.

    3D structure databases

    ProteinModelPortali B8HCF5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 452863.Achl_2606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL40571 ; ACL40571 ; Achl_2606 .
    GeneIDi 7294082.
    KEGGi ach:Achl_2606.
    PATRICi 20991851. VBIArtChl38304_3293.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi IYSHLAL.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ACHL452863:GH1A-2659-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360Imported.

    Entry informationi

    Entry nameiB8HCF5_ARTCA
    AccessioniPrimary (citable) accession number: B8HCF5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3