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B8HCE1

- DNLI_ARTCA

UniProt

B8HCE1 - DNLI_ARTCA

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Protein
Probable DNA ligase
Gene
lig, Achl_2592
Organism
Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATP By similarity
Active sitei211 – 2111N6-AMP-lysine intermediate By similarity
Binding sitei216 – 2161ATP By similarity
Binding sitei231 – 2311ATP By similarity
Binding sitei260 – 2601ATP By similarity
Binding sitei295 – 2951ATP By similarity
Binding sitei366 – 3661ATP By similarity
Binding sitei372 – 3721ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACHL452863:GH1A-2645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:Achl_2592
OrganismiArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter
ProteomesiUP000002505: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Probable DNA ligaseUniRule annotation
PRO_1000134726Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_2592.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8HCE1-1 [UniParc]FASTAAdd to Basket

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MLLDELVRTT DAVASTRSRL AKVDALAQLL KRLDPADIPA AVGLLTAKPR    50
QGRVGVGWRG MSAAMGEPAA DPGLTLADLD AALDRLQALA GAGSAAERAA 100
TLRGLTAAAT EREQAFIGGV LLGELRTGAL EGVLTDAVAR AAERSVEAVR 150
RAAMLSGDLG STALLALTGT AAELDAVGLK VGRPVQPMLA GTGASVTAAL 200
ETTGEASVEY KLDGARIQVH RSGGDVRIFT RTLAEVTHRL PEVVEVVRGF 250
PVHDVILDGE TLALGEDGAP RPFQETMSRF GADAARTTVL HPWFFDVLHI 300
DGRDLLDEPL SERIKVLEAI APAHRIPGEI TADPEVAGRI SRDALAAGHE 350
GVMLKSVGSL YAAGRRGSNW IKVKPVLTYD LVVLACEWGS GRRTGMLSNL 400
HLGALDPAGE YGEPGGYVMV GKTFKGLTDA LLQWQTKRFQ EIEVRRTAGT 450
VWVEPVTVVE IAIDGVQQSP RYPGRIALRF ARVKGYREDK TAAEADTIQT 500
LRALLRP 507
Length:507
Mass (Da):53,789
Last modified:March 3, 2009 - v1
Checksum:i9E1C6A041783ACB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001341 Genomic DNA. Translation: ACL40557.1.
RefSeqiYP_002488646.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL40557; ACL40557; Achl_2592.
GeneIDi7294068.
KEGGiach:Achl_2592.
PATRICi20991825. VBIArtChl38304_3280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001341 Genomic DNA. Translation: ACL40557.1 .
RefSeqi YP_002488646.1. NC_011886.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452863.Achl_2592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL40557 ; ACL40557 ; Achl_2592 .
GeneIDi 7294068.
KEGGi ach:Achl_2592.
PATRICi 20991825. VBIArtChl38304_3280.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci ACHL452863:GH1A-2645-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Entry informationi

Entry nameiDNLI_ARTCA
AccessioniPrimary (citable) accession number: B8HCE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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