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Protein

Probable DNA ligase

Gene

lig

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1
Active sitei211N6-AMP-lysine intermediateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei231ATPUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei366ATPUniRule annotation1
Binding sitei372ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Achl_2592
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001347261 – 507Probable DNA ligaseAdd BLAST507

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_2592

Structurei

3D structure databases

SMRiB8HCE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

B8HCE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDELVRTT DAVASTRSRL AKVDALAQLL KRLDPADIPA AVGLLTAKPR
60 70 80 90 100
QGRVGVGWRG MSAAMGEPAA DPGLTLADLD AALDRLQALA GAGSAAERAA
110 120 130 140 150
TLRGLTAAAT EREQAFIGGV LLGELRTGAL EGVLTDAVAR AAERSVEAVR
160 170 180 190 200
RAAMLSGDLG STALLALTGT AAELDAVGLK VGRPVQPMLA GTGASVTAAL
210 220 230 240 250
ETTGEASVEY KLDGARIQVH RSGGDVRIFT RTLAEVTHRL PEVVEVVRGF
260 270 280 290 300
PVHDVILDGE TLALGEDGAP RPFQETMSRF GADAARTTVL HPWFFDVLHI
310 320 330 340 350
DGRDLLDEPL SERIKVLEAI APAHRIPGEI TADPEVAGRI SRDALAAGHE
360 370 380 390 400
GVMLKSVGSL YAAGRRGSNW IKVKPVLTYD LVVLACEWGS GRRTGMLSNL
410 420 430 440 450
HLGALDPAGE YGEPGGYVMV GKTFKGLTDA LLQWQTKRFQ EIEVRRTAGT
460 470 480 490 500
VWVEPVTVVE IAIDGVQQSP RYPGRIALRF ARVKGYREDK TAAEADTIQT

LRALLRP
Length:507
Mass (Da):53,789
Last modified:March 3, 2009 - v1
Checksum:i9E1C6A041783ACB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA Translation: ACL40557.1
RefSeqiWP_015937767.1, NC_011886.1

Genome annotation databases

EnsemblBacteriaiACL40557; ACL40557; Achl_2592
KEGGiach:Achl_2592

Similar proteinsi

Entry informationi

Entry nameiDNLI_PSECP
AccessioniPrimary (citable) accession number: B8HCE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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