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B8HCE1 (DNLI_ARTCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Achl_2592
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Probable DNA ligase HAMAP-Rule MF_00407
PRO_1000134726

Sites

Active site2111N6-AMP-lysine intermediate By similarity
Binding site2091ATP By similarity
Binding site2161ATP By similarity
Binding site2311ATP By similarity
Binding site2601ATP By similarity
Binding site2951ATP By similarity
Binding site3661ATP By similarity
Binding site3721ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8HCE1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 9E1C6A041783ACB4

FASTA50753,789
        10         20         30         40         50         60 
MLLDELVRTT DAVASTRSRL AKVDALAQLL KRLDPADIPA AVGLLTAKPR QGRVGVGWRG 

        70         80         90        100        110        120 
MSAAMGEPAA DPGLTLADLD AALDRLQALA GAGSAAERAA TLRGLTAAAT EREQAFIGGV 

       130        140        150        160        170        180 
LLGELRTGAL EGVLTDAVAR AAERSVEAVR RAAMLSGDLG STALLALTGT AAELDAVGLK 

       190        200        210        220        230        240 
VGRPVQPMLA GTGASVTAAL ETTGEASVEY KLDGARIQVH RSGGDVRIFT RTLAEVTHRL 

       250        260        270        280        290        300 
PEVVEVVRGF PVHDVILDGE TLALGEDGAP RPFQETMSRF GADAARTTVL HPWFFDVLHI 

       310        320        330        340        350        360 
DGRDLLDEPL SERIKVLEAI APAHRIPGEI TADPEVAGRI SRDALAAGHE GVMLKSVGSL 

       370        380        390        400        410        420 
YAAGRRGSNW IKVKPVLTYD LVVLACEWGS GRRTGMLSNL HLGALDPAGE YGEPGGYVMV 

       430        440        450        460        470        480 
GKTFKGLTDA LLQWQTKRFQ EIEVRRTAGT VWVEPVTVVE IAIDGVQQSP RYPGRIALRF 

       490        500 
ARVKGYREDK TAAEADTIQT LRALLRP 

« Hide

References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001341 Genomic DNA. Translation: ACL40557.1.
RefSeqYP_002488646.1. NC_011886.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING452863.Achl_2592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL40557; ACL40557; Achl_2592.
GeneID7294068.
KEGGach:Achl_2592.
PATRIC20991825. VBIArtChl38304_3280.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAARVQVHK.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycACHL452863:GH1A-2645-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_ARTCA
AccessionPrimary (citable) accession number: B8HCE1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families