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Protein

Probable DNA ligase

Gene

lig

Organism
Arthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / JCM 12360 / NCIMB 13794 / A6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATPUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
Binding sitei216 – 2161ATPUniRule annotation
Binding sitei231 – 2311ATPUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei295 – 2951ATPUniRule annotation
Binding sitei366 – 3661ATPUniRule annotation
Binding sitei372 – 3721ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACHL452863:GH1A-2645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Achl_2592
OrganismiArthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / JCM 12360 / NCIMB 13794 / A6)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeArthrobacter
ProteomesiUP000002505 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Probable DNA ligasePRO_1000134726Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_2592.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8HCE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDELVRTT DAVASTRSRL AKVDALAQLL KRLDPADIPA AVGLLTAKPR
60 70 80 90 100
QGRVGVGWRG MSAAMGEPAA DPGLTLADLD AALDRLQALA GAGSAAERAA
110 120 130 140 150
TLRGLTAAAT EREQAFIGGV LLGELRTGAL EGVLTDAVAR AAERSVEAVR
160 170 180 190 200
RAAMLSGDLG STALLALTGT AAELDAVGLK VGRPVQPMLA GTGASVTAAL
210 220 230 240 250
ETTGEASVEY KLDGARIQVH RSGGDVRIFT RTLAEVTHRL PEVVEVVRGF
260 270 280 290 300
PVHDVILDGE TLALGEDGAP RPFQETMSRF GADAARTTVL HPWFFDVLHI
310 320 330 340 350
DGRDLLDEPL SERIKVLEAI APAHRIPGEI TADPEVAGRI SRDALAAGHE
360 370 380 390 400
GVMLKSVGSL YAAGRRGSNW IKVKPVLTYD LVVLACEWGS GRRTGMLSNL
410 420 430 440 450
HLGALDPAGE YGEPGGYVMV GKTFKGLTDA LLQWQTKRFQ EIEVRRTAGT
460 470 480 490 500
VWVEPVTVVE IAIDGVQQSP RYPGRIALRF ARVKGYREDK TAAEADTIQT

LRALLRP
Length:507
Mass (Da):53,789
Last modified:March 3, 2009 - v1
Checksum:i9E1C6A041783ACB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL40557.1.
RefSeqiWP_015937767.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL40557; ACL40557; Achl_2592.
KEGGiach:Achl_2592.
PATRICi20991825. VBIArtChl38304_3280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL40557.1.
RefSeqiWP_015937767.1. NC_011886.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi452863.Achl_2592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL40557; ACL40557; Achl_2592.
KEGGiach:Achl_2592.
PATRICi20991825. VBIArtChl38304_3280.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.
OrthoDBiEOG6Q8HXT.

Enzyme and pathway databases

BioCyciACHL452863:GH1A-2645-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700700 / DSM 12829 / JCM 12360 / NCIMB 13794 / A6.

Entry informationi

Entry nameiDNLI_ARTCA
AccessioniPrimary (citable) accession number: B8HCE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.