B8HBR4 (B8HBR4_ARTCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Achl_2487

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515 EMBL ACL40452.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	197	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	249	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	234	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	207	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	218	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	275	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	314	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	B8HBR4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 38CB8594C69A9F1D	FASTA	327	35,083
	10 20 30 40 50 60 MTFPSQRPRR LRTTPAMRRL TAETRLASAE LILPAFIREG ITEPNPITSM PGVVQHTSDS 70 80 90 100 110 120 LKRAAAEAVE LGLGGIMLFG IPETRDAEGT ASLDPQGVLN KAIRDVRAEV GDDLVIMSDV 130 140 150 160 170 180 CLDEFTDHGH CGVLDADGYV DNDRTVEIYA RMAVAQAEAG AHMLGPSGMM DGQIAAIRAA 190 200 210 220 230 240 LDDAGHANTS VIAYSAKYAS AFYGPFREAV DSQLKGDRRT YQMDAGNRTE ALREVELDLA 250 260 270 280 290 300 EGADIVMVKP AMSYLDIVAD VAAMSPVPVA AYQISGEYAM IEAAAANGWI DRRAAIAESV 310 320 LGIRRAGAHM VLTYWAAELA GWLKEGR

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL40452.1.
RefSeq	YP_002488541.1. NC_011886.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8HBR4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7293962.
GenomeReviews	Gene locus Achl_2487 in contig CP001341_GR.
KEGG	ach:Achl_2487.
PATRIC	20991611. VBIArtChl38304_3174.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	FTSHGHD.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8HBR4_ARTCA

Accession

Primary (citable) accession number: B8HBR4

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)