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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi326Magnesium or manganese 11
Metal bindingi339Magnesium or manganese 11
Metal bindingi339Magnesium or manganese 21
Metal bindingi341Magnesium or manganese 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 248ATPAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddl
Ordered Locus Names:Achl_2251
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001174461 – 382D-alanine--D-alanine ligaseAdd BLAST382

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_2251.

Structurei

3D structure databases

ProteinModelPortaliB8HAC4.
SMRiB8HAC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 372ATP-graspAdd BLAST212

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011593.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom_sf.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B8HAC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKDLTSGE PAGRPKPRVA VLFGGRSSEH AVSCVTAAGV LGAINKDKYD
60 70 80 90 100
VIPIGIAKSG QWVLAGGDTA QWSLAGKALP EVAPSEQTVT LAEIGGEHQL
110 120 130 140 150
IVAAPNEVPQ ELGTVDVVFP LLHGPFGEDG TIQGLLELSD TRYVGAGVLA
160 170 180 190 200
SAVGMDKHFM KVVFESAGLH VGPYVAVTDR QWQKDPEAVR KQVDRLGFPV
210 220 230 240 250
FVKPARAGSS MGISKVDSLE GLDAAIEEAR RHDLKLVIEA GIVGREIECA
260 270 280 290 300
VLEGRGTDAP RTSLPGEISV AGGGHEFYDF NAKYVEDDAA SLSCPADIPD
310 320 330 340 350
EAIARVRELA AAAFDAVGAE GLSRVDFFYT PDGDLIINEI NTMPGFTPKS
360 370 380
MYPQMWAKSG LGYAELIDEL IHLALNRKTG LR
Length:382
Mass (Da):40,523
Last modified:March 3, 2009 - v1
Checksum:i10D3114381BE1BCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL40216.1.
RefSeqiWP_015937431.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL40216; ACL40216; Achl_2251.
KEGGiach:Achl_2251.

Similar proteinsi

Entry informationi

Entry nameiDDL_PSECP
AccessioniPrimary (citable) accession number: B8HAC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families