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B8HA82 (B8HA82_ARTCA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH1 HAMAP MF_01815
Ordered Locus Names:Achl_2206
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region279 – 2835ACP-binding By similarity HAMAP MF_01815

Sites

Active site1241 By similarity HAMAP MF_01815
Active site2781 By similarity HAMAP MF_01815
Active site3091 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B8HA82 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: A33671E6602C15C1

FASTA35337,033
        10         20         30         40         50         60 
MSVPTLKQAP LQEHTRILGL GAFRPGVIVT NDDVCQWIDS SDEWIRQRTG IVTRHRAAAD 

        70         80         90        100        110        120 
VSVIDMAEGA AREALAKAGI EATDLGAVIV STVTHPYATP SAAASLADRL GATPAPAFDI 

       130        140        150        160        170        180 
SAACAGYCYG IAQADALVRS GAAKYVLVVG AEKLSDVIDN RERTISFLLG DGAGAVVIGP 

       190        200        210        220        230        240 
SDTPGIAPSV WGSDGSKWDA IGMTRSLLDV RDLGMAARQS DSTGDLALLE EAQELYPTLR 

       250        260        270        280        290        300 
QDGQTVFRWA VWEMAKVAQQ ALDAAGVEAE DLVAFIPHQA NMRIIDEMVK KLKLPETVTV 

       310        320        330        340        350 
ARDIADAGNT SAASIPLATH RLLQENPELS GGLALQIGFG AGLVFGAQVV VLP

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References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001341 Genomic DNA. Translation: ACL40174.1.
RefSeqYP_002488263.1. NC_011886.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8HA82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7293674.
GenomeReviewsGene locus Achl_2206 in contig CP001341_GR.
KEGGach:Achl_2206.
PATRIC20991021. VBIArtChl38304_2886.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAATRIEND.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 3 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8HA82_ARTCA
AccessionPrimary (citable) accession number: B8HA82
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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