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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Achl_2194
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001845581 – 174Peptide methionine sulfoxide reductase MsrAAdd BLAST174

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_2194

Structurei

3D structure databases

ProteinModelPortaliB8HA70
SMRiB8HA70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXP Bacteria
COG0225 LUCA
HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

B8HA70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFVLGGGC FWCLDAVYQK TKGVTAVVSG YTGGHDPYPD YYSVCSGTTG
60 70 80 90 100
HAEVVAVTFD EEIIPAEVIL DMFFALHDPT TLNRQGYDVG TQYRSSMFYE
110 120 130 140 150
TTEEKILFEE AIDRNQALWS HPIVTEVSRL PRFHVAEEFH QDYYAKHPEQ
160 170
GYCQVIINPK LAKARKYYSA WLNA
Length:174
Mass (Da):19,810
Last modified:March 3, 2009 - v1
Checksum:i9666444418AEE511
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA Translation: ACL40162.1
RefSeqiWP_015937379.1, NC_011886.1

Genome annotation databases

EnsemblBacteriaiACL40162; ACL40162; Achl_2194
KEGGiach:Achl_2194

Similar proteinsi

Entry informationi

Entry nameiMSRA_PSECP
AccessioniPrimary (citable) accession number: B8HA70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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