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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

Achl_0351

Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (Achl_0351)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciACHL452863:GH1A-354-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:Achl_0351
OrganismiPseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6) (Arthrobacter chlorophenolicus)
Taxonomic identifieri452863 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaePseudarthrobacter
Proteomesi
  • UP000002505 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Probable 5-dehydro-4-deoxyglucarate dehydratasePRO_1000147906Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi452863.Achl_0351.

Structurei

3D structure databases

ProteinModelPortaliB8H9W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.
OrthoDBiEOG6W7235.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

B8H9W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKYTPNELA DTLKEGLLSF PVTSFDANLQ FDEENYRKHL AWQASFPVAG
60 70 80 90 100
LFAAGGTGEG FSLTPAESER VVRTAVDEVG SRVPVLASAG GSTAQAIENA
110 120 130 140 150
KAAEAAGADG ILLLPPYLTE ADQAGLVEHV SAVCRATSLG VIIYNRANAI
160 170 180 190 200
YKDTTVATLA DRHANLIGFK DGVGDLEHDA RVYAKLGDRL FYLGGLPTAE
210 220 230 240 250
TFALPLLQLG MSTYSSAMYN FVPQFALDFY QDVRNQDRAA VNKKLNDFVI
260 270 280 290 300
PYLDIRDRVK GYSVSIVKGG LDAIGRSAGP VRTPLQNLAP QDLADLKALI

ATVS
Length:304
Mass (Da):32,503
Last modified:March 3, 2009 - v1
Checksum:i47B579F6462E0B19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL38350.1.
RefSeqiWP_015935577.1. NC_011886.1.

Genome annotation databases

EnsemblBacteriaiACL38350; ACL38350; Achl_0351.
KEGGiach:Achl_0351.
PATRICi20987177. VBIArtChl38304_1005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001341 Genomic DNA. Translation: ACL38350.1.
RefSeqiWP_015935577.1. NC_011886.1.

3D structure databases

ProteinModelPortaliB8H9W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi452863.Achl_0351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL38350; ACL38350; Achl_0351.
KEGGiach:Achl_0351.
PATRICi20987177. VBIArtChl38304_1005.

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.
OrthoDBiEOG6W7235.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciACHL452863:GH1A-354-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6.

Entry informationi

Entry nameiKDGD_PSECP
AccessioniPrimary (citable) accession number: B8H9W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.