B8H8U9 (PYRB_ARTCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Achl_2003

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000116121

Sequences

	Sequence		Length	Mass (Da)
	B8H8U9 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 4F722827227A4800	FASTA	342	36,884
	10 20 30 40 50 60 MKHLLSTQDL SLHNAIRILD TAEEMSAVGD REVKKLPALR GRTVVNLFFE DSTRTRISFE 70 80 90 100 110 120 AAAKRLSADV INFAAKGSSV SKGESLKDTA QTLSAMGADA VVIRHWASGA PHRLAATDWI 130 140 150 160 170 180 DAGVINAGDG THEHPTQALL DAFTMRRHWA KLSGTPSEGA DLKGMRVAIA GDVLHSRVAR 190 200 210 220 230 240 SNVWLLRTLG AEVTLVAPPT LLPIGVEKWP CAVSYDLDET LARGVDAVMM LRVQGERMNA 250 260 270 280 290 300 SFFPSTREYS RRWGFDDNRL RALDSLGMKD TIIMHPGPMN RGLEISAAAA DSPRSTVLAQ 310 320 330 340 VRNGVSVRMA ALYLLLSGDT RETAAPPVLA AAGTAHSTKE SI

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL39977.1.
RefSeq	YP_002488066.1. NC_011886.1.
3D structure databases
ProteinModelPortal	B8H8U9.
ModBase	Search...
Protein-protein interaction databases
STRING	B8H8U9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7293464.
GenomeReviews	Gene locus Achl_2003 in contig CP001341_GR.
KEGG	ach:Achl_2003.
PATRIC	20990587. VBIArtChl38304_2676.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	LQRERMS.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ARTCA

Accession

Primary (citable) accession number: B8H8U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program