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B8H8T1 (GLPK_ARTCA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Achl_1985
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Glycerol kinase HAMAP MF_00186
PRO_1000124178

Regions

Nucleotide binding413 – 4175ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1341Substrate By similarity
Binding site2461Substrate By similarity
Binding site2681ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
B8H8T1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: FB8773DA4A5D9D0A

FASTA50454,985
        10         20         30         40         50         60 
MNQYVIAIDQ GTTSTRAIIF DHSGAIVSSG QMEHEQIFPK AGWVEHDAAE IWNNTREVIA 

        70         80         90        100        110        120 
SALSKANLTR HDIAAVGITN QRETAVVWDK TTGEPVYNAI VWQDTRTQDI VDELSKDGGG 

       130        140        150        160        170        180 
DRFKQKVGLP LATYFSGTKI KWILDNVDGA REKAEAGNLV FGNTDCWVLW NLTGGVDGGV 

       190        200        210        220        230        240 
HVTDVTNASR TLFMDLETLQ WDEEILGIFG VPRSMMPEIK SSSEVYGTVH TSQLLRETPV 

       250        260        270        280        290        300 
AGILGDQQAA TFGQAAFETG EAKNTYGTGC FLIFNTGEEI VHSKNGLLTT VGYKLGDAKP 

       310        320        330        340        350        360 
HYALEGSIAV TGSLIQWLRD NLGMISSAPE VETLAASVKD NGGVYIVPAF SGLFAPYWRP 

       370        380        390        400        410        420 
DARGAIVGLT RFVNKNHIAR AALESTAFQT REVLDAVNAD SGVPLTELKV DGGMVANDAL 

       430        440        450        460        470        480 
MQFQADILGV PVIRPKVIET TALGAAYAAG LAVGFWKDLG ELSSNWSEDK RWEPQLDQAE 

       490        500 
QERQMRLWRK AVTKSMDWVD EDVK

« Hide

References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001341 Genomic DNA. Translation: ACL39959.1.
RefSeqYP_002488048.1. NC_011886.1.

3D structure databases

ProteinModelPortalB8H8T1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8H8T1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7293446.
GenomeReviewsGene locus Achl_1985 in contig CP001341_GR.
KEGGach:Achl_1985.
PATRIC20990551. VBIArtChl38304_2658.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMAATYFSGT.
ProtClustDBCLSK928226.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_ARTCA
AccessionPrimary (citable) accession number: B8H8T1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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