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B8H8K7 (UPPP_ARTCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Achl_1910
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeArthrobacter

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148800

Regions

Transmembrane88 – 10821Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane157 – 17923Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane255 – 27521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B8H8K7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: F6DD4AD29F808A42

FASTA27730,166
        10         20         30         40         50         60 
MNWFEVALLG LVQGLTEFLP ISSSAHLRIV GQFLPNAEDP GAAFTAITQL GTETAVVVYF 

        70         80         90        100        110        120 
WRDIVRIVKA WAGSLAGKVS RQDPDARMGW LVILGSLPII VLGLLFQDQI ESVLRSMWIV 

       130        140        150        160        170        180 
ATMLIVFGLI LAVADAVGKQ ERDLTQLTYK HGILYGFAQA MALIPGVSRS GGTITAGLLM 

       190        200        210        220        230        240 
GYTREAAARY SFLLAIPAVF GSGLYQLYKV VSKDGITGPY GLPETALATV IAFVVGYVII 

       250        260        270 
GWFLKFVSTR SYRLFVWYRI FLGLALYLLL GFGVISA 

« Hide

References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001341 Genomic DNA. Translation: ACL39885.1.
RefSeqYP_002487974.1. NC_011886.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING452863.Achl_1910.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL39885; ACL39885; Achl_1910.
GeneID7293371.
KEGGach:Achl_1910.
PATRIC20990399. VBIArtChl38304_2582.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycACHL452863:GH1A-1948-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ARTCA
AccessionPrimary (citable) accession number: B8H8K7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families