B8H806 (AROE_ARTCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Achl_3856

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000124871
Regions
	Nucleotide binding	136 – 140	5	NADP By similarity
Sites
	Active site	76	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B8H806 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 942B41289853F04C	FASTA	293	31,016
	10 20 30 40 50 60 MSQRTESYLV GLVGDGVTPS LTPPMHEREG DVQGLRYLYR PIDLLELGLA GDSVGEVLRS 70 80 90 100 110 120 ARTLGFNGLN ITHPCKQLVL QHLDEVSPDA RRLGAVNTVV IRDGRFIGHN TDFSGFAAAL 130 140 150 160 170 180 ASGLPGARLD RVVQLGAGGA GSAVAYALLS AGAKTLDLVD MDAERAAARA EELSGFFPDS 190 200 210 220 230 240 TVTARTTADL PQLMPLADGL VHCTPVGMAA HPGVPLDLEL LESRHWVADI VYRPIDTELV 250 260 270 280 290 QGARAKGCDV LDGGRMAVGQ AADAFRIFTG LDADPERMRS HFLELVAAEE VAA

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL41809.1.
RefSeq	YP_002489898.1. NC_011886.1.
3D structure databases
ProteinModelPortal	B8H806.
ModBase	Search...
Protein-protein interaction databases
STRING	B8H806.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7295344.
GenomeReviews	Gene locus Achl_3856 in contig CP001341_GR.
KEGG	ach:Achl_3856.
PATRIC	20994367. VBIArtChl38304_4539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	HEHEGDA.
ProtClustDB	PRK12549.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROE_ARTCA

Accession

Primary (citable) accession number: B8H806

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program