B8H7C8 (B8H7C8_ARTCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377
Ordered Locus Names:	Achl_0001

Organism

Arthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]

Taxonomic identifier

452863 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377 RuleBase RU000577
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377 RuleBase RU004227

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377 RuleBase RU000577
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 RuleBase RU000577 DNA-binding HAMAP MF_00377 RuleBase RU000577 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	172 – 179	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	B8H7C8 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 69EC908B33EF96AD	FASTA	473	53,269
	10 20 30 40 50 60 MTVDEANHAN TVGSSWRRVI SLLENDHRVT PRQRGFVILA QAQGLIGSTL LVAVPNELTR 70 80 90 100 110 120 EVLQTQVKDA LDDALHNVFS EDIRCAIDVD TDLVPIHKEP EPVVEPAYAQ DQLIEQKPQP 130 140 150 160 170 180 MLPSTSHEFG RLNPKYVFDT FVIGSSNRFA HAAAVAVAEA PAKAYNPLFI YGDSGLGKTH 190 200 210 220 230 240 LLHAIGHYAR RLYSGIRVRY VNSEEFTNDF INSIRDDEGA SFKTTYRNVD VLLIDDIQFL 250 260 270 280 290 300 AGKDRTLEEF FHTFNSLHNN NKQVVITSDQ PPKLLAGFED RMKSRFEWGL LTDIQPPELE 310 320 330 340 350 360 TRIAILRKKA LSEGLSAPDD ALEYIASKIS SNIRELEGAL IRVTAFASLN RQPVDVALAE 370 380 390 400 410 420 MVLKDLITDD GAQEITSGQI LQQTADYFKL SMEELCSKSR TRTLVTARQI AMYLCRELTD 430 440 450 460 470 MSLPKIGQEL GGRDHTTVIH ADRKIRELMA ERRVIYNQVT ELTNRIKQQQ RDS

References

[1]

"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001341 Genomic DNA. Translation: ACL38004.1.
RefSeq	YP_002486093.1. NC_011886.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8H7C8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7295425.
GenomeReviews	Gene locus Achl_0001 in contig CP001341_GR.
KEGG	ach:Achl_0001.
PATRIC	20986463. VBIArtChl38304_0651.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	DEVAFLI.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8H7C8_ARTCA

Accession

Primary (citable) accession number: B8H7C8

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)