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B8H6T7 (B8H6T7_ARTCA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase HAMAP MF_00180
Short name=DHBP synthase HAMAP MF_00180
EC=4.1.99.12 HAMAP MF_00180
Gene names
Name:ribB HAMAP MF_00180
Ordered Locus Names:Achl_1671
OrganismArthrobacter chlorophenolicus (strain A6 / ATCC 700700 / DSM 12829 / JCM 12360) [Complete proteome] [HAMAP]
Taxonomic identifier452863 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Arthrobacter

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity. HAMAP MF_00180 SAAS SAAS000422

Catalytic activity

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate. HAMAP MF_00180 SAAS SAAS000422

Cofactor

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity. HAMAP MF_00180 SAAS SAAS000422

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. HAMAP MF_00180 RuleBase RU003843 SAAS SAAS000422

Subunit structure

Homodimer By similarity. HAMAP MF_00180 SAAS SAAS000422

Sequence similarities

Belongs to the DHBP synthase family. HAMAP MF_00180 RuleBase RU003843

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region45 – 462Substrate binding By similarity HAMAP MF_00180
Region158 – 1625Substrate binding By similarity HAMAP MF_00180

Sites

Metal binding461Magnesium or manganese 1 By similarity HAMAP MF_00180
Metal binding461Magnesium or manganese 2 By similarity HAMAP MF_00180
Metal binding1611Magnesium or manganese 2 By similarity HAMAP MF_00180
Binding site501Substrate By similarity HAMAP MF_00180
Binding site1821Substrate By similarity HAMAP MF_00180
Site1441Essential for catalytic activity By similarity HAMAP MF_00180
Site1821Essential for catalytic activity By similarity HAMAP MF_00180

Sequences

Sequence LengthMass (Da)Tools
B8H6T7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C373E73A619F9BFC

FASTA24025,021
        10         20         30         40         50         60 
MNATARLEPG AVPAVIPARG LDSIDDAVRA MAAGKPVLVV DNEDRENEGD IIFAAQHATP 

        70         80         90        100        110        120 
ALMGWTIRYS SGVICVPLTG ERADALELPP MTAVNEDAKG TAYTVSCDAA IGVSTGISAT 

       130        140        150        160        170        180 
DRALTARVLA DPQALPASVT RPGHIFPLRA VDGGVRERQG HTEAAVDLCR LAGLEPVGVI 

       190        200        210        220        230        240 
AEVVYDDGEM MRLDGLRSFA AEHGCPLVSI EDLVAYLEAG TGGGLDQNVR TVPGGEKEKR

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References

[1]"Complete sequence of chromosome of Arthrobacter chlorophenolicus A6."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Goltsman E., Clum A., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Jansson J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A6 / ATCC 700700 / DSM 12829 / JCM 12360.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001341 Genomic DNA. Translation: ACL39658.1.
RefSeqYP_002487747.1. NC_011886.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8H6T7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7293130.
GenomeReviewsGene locus Achl_1671 in contig CP001341_GR.
KEGGach:Achl_1671.
PATRIC20989923. VBIArtChl38304_2346.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG735778.
OMAGDMIFAA.
ProtClustDBCLSK959805.

Family and domain databases

HAMAPMF_00180. RibB.
[Tree]
InterProIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
Gene3DG3DSA:3.90.870.10. DHBP_synth_RibB-like_a/b_dom. 1 hit.
KOK02858.
PfamPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMsTIGR00506. RibB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8H6T7_ARTCA
AccessionPrimary (citable) accession number: B8H6T7
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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