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B8H6C3

- UPPP_CAUCN

UniProt

B8H6C3 - UPPP_CAUCN

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciCAULONA1000:CCNA_03719-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:CCNA_03719
    OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
    Taxonomic identifieri565050 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001364: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatasePRO_1000148806Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190650.CC_3605.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei46 – 6621HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei105 – 12521HelicalUniRule annotationAdd
    BLAST
    Transmembranei142 – 16221HelicalUniRule annotationAdd
    BLAST
    Transmembranei182 – 20221HelicalUniRule annotationAdd
    BLAST
    Transmembranei216 – 23621HelicalUniRule annotationAdd
    BLAST
    Transmembranei244 – 26421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8H6C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDWLIALIL GLIEGLTEFI PVSSTGHLLL LGHFLGFHSP GNTFQVLIQL    50
    GAILAITGVY FGRLWGLLTT LPTEPGSRRF VIGILLAFLP AVFVGVAAHD 100
    FIKTVLYETP ALVCSTLIIG GFILLALDRM KLEPRYTDVA EYPLKTAFII 150
    GLFQCLALVP GVSRSGATIA GALLLKCDKR SAAEFSFFLA MPTMAGAFAY 200
    DLYKNIDKLS TNDLGLIGIG FLAALVSGVF VVKTVLDFIT RHGFAPFAYW 250
    RIAVGVVGLA LLYIPR 266
    Length:266
    Mass (Da):28,709
    Last modified:March 3, 2009 - v1
    Checksum:iB9BA8F7E6B5B7119
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL97184.1.
    RefSeqiYP_002519092.1. NC_011916.1.

    Genome annotation databases

    EnsemblBacteriaiACL97184; ACL97184; CCNA_03719.
    GeneIDi7331915.
    KEGGiccs:CCNA_03719.
    PATRICi21311929. VBICauCre52860_3626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL97184.1 .
    RefSeqi YP_002519092.1. NC_011916.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190650.CC_3605.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL97184 ; ACL97184 ; CCNA_03719 .
    GeneIDi 7331915.
    KEGGi ccs:CCNA_03719.
    PATRICi 21311929. VBICauCre52860_3626.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci CAULONA1000:CCNA_03719-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
      Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
      J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1000 / CB15N.

    Entry informationi

    Entry nameiUPPP_CAUCN
    AccessioniPrimary (citable) accession number: B8H6C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3