B8H555 (ARGC_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CCNA_01442

Organism

Caulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]

Taxonomic identifier

565050 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm By similarity HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_01110		PRO_1000163994
Sites
	Active site	118	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8H555 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: FC798C7D3EE74561	FASTA	317	33,278
	10 20 30 40 50 60 MANAPKVFID GEAGTTGLQI RERLVGRTDL QLISIDPDKR KDADARAEML NSADAVILCL 70 80 90 100 110 120 PDDAAKEAVS LVSNPNTVII DASTAYRTAE GWAYGFAELD SEQRGKIAAS KRISNPGCYP 130 140 150 160 170 180 TGAIALTRPL VSAGILPAEL PVSYNAVSGY TGGGKAMIAQ FEDESAADHT RAPYFIYGLS 190 200 210 220 230 240 LSHKHVPEMQ KHGGLLTRPI FTPAVGRYAQ GMIVEMPLHL STLNGAPSLA DIHAALVKHY 250 260 270 280 290 300 KGEAFVEVAS LDEAKALTTL DPEGLNGTNR LKLFVFGSDA GGQARLVALL DNLGKGASGA 310 AVQNLNIALG LDEAAGL

References

[1]

"The genetic basis of laboratory adaptation in Caulobacter crescentus." Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S. J. Bacteriol. 192:3678-3688(2010) [PubMed: 20472802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NA1000 / CB15N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001340 Genomic DNA. Translation: ACL94907.1.
RefSeq	YP_002516815.1. NC_011916.1.
3D structure databases
ProteinModelPortal	B8H555.
ModBase	Search...
Protein-protein interaction databases
STRING	B8H555.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7330172.
GenomeReviews	Gene locus CCNA_01442 in contig CP001340_GR.
KEGG	ccs:CCNA_01442.
PATRIC	21307455. VBICauCre52860_1426.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PIFVPSV.
ProtClustDB	PRK11863.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CAUCN

Accession

Primary (citable) accession number: B8H555

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program