B8H4W6 (KHSE_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	CCNA_03475

Organism

Caulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]

Taxonomic identifier

565050 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Homoserine kinase HAMAP MF_00301		PRO_1000196944

Sequences

	Sequence		Length	Mass (Da)
	B8H4W6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 97C9304EB6508C8A	FASTA	317	35,025
	10 20 30 40 50 60 MAVYTDITDQ ELEAFLEGYD LGAPLAFKGI AEGVENSNFL LETEKGRYIL TVYERRVKAE 70 80 90 100 110 120 DLPYFLNMLT WLADRGYPSA RPIPTRSGAT LSSLRGKPAA IVEFLPGLSV RKPTAAHCRE 130 140 150 160 170 180 AGEGLAWLHL AGEGYPGRRA NDLGQAAWSP LFSKHRKAAE DLKPGLSATI DNDLAQLSLM 190 200 210 220 230 240 WPRNLPTGTI HADYFPDNVF FQSNGKFAAA IDFYFACDDA YAYDVAVTLN AWCFEADGSF 250 260 270 280 290 300 NITAAKALLN GYERRRPLSP IEKEALPILA RGAAMRFFLT RLADWGSTPA GALVRPKDPL 310 EYERKLAVHR EGLVLFA

References

[1]

"The genetic basis of laboratory adaptation in Caulobacter crescentus." Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S. J. Bacteriol. 192:3678-3688(2010) [PubMed: 20472802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NA1000 / CB15N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001340 Genomic DNA. Translation: ACL96940.1.
RefSeq	YP_002518848.1. NC_011916.1.
3D structure databases
ProteinModelPortal	B8H4W6.
SMR	B8H4W6. Positions 5-311.
ModBase	Search...
Protein-protein interaction databases
STRING	B8H4W6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7332472.
GenomeReviews	Gene locus CCNA_03475 in contig CP001340_GR.
KEGG	ccs:CCNA_03475.
PATRIC	21311439. VBICauCre52860_3389.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_CAUCN

Accession

Primary (citable) accession number: B8H4W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program