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B8H4V4 (GCSPA_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:CCNA_03463
OrganismCaulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]
Taxonomic identifier565050 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147980

Sequences

Sequence LengthMass (Da)Tools
B8H4V4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: D62740DA0E84303F

FASTA44847,298
        10         20         30         40         50         60 
MRYLPLTPED RVEMLGAIGV KSIDDLFVDV PVSARRDAPV DLPHHAGELD VEREMAGLAR 

        70         80         90        100        110        120 
RNRAAGEGPF FCGAGAYRHH VPATVDHIIQ RSEFLTSYTP YQPEIAQGTL QVLFEFQTQV 

       130        140        150        160        170        180 
AALTGMEVAN ASLYDGSTGA AEAVMMAQRV TRRNKAVMSG GVHPHYVGAI ETLAHAAGVA 

       190        200        210        220        230        240 
TQALPAAVDA EDAVIAAIDQ DTACVVVQTP NVFGTVTDVS KIAEAAHAAG ALLIVVTTEA 

       250        260        270        280        290        300 
VSFGLLKSPG EMGADIAVAE GQSIGNGLNF GGPYVGLFAC KEKFVRQMPG RLCGETVDAD 

       310        320        330        340        350        360 
GKRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGETGLRQ LAAVNHQKAL 

       370        380        390        400        410        420 
ALRDALKAVP GVEILTPRFF NEFAIRVPGK AAEVVEILAA HGVIAGVPFS RLDAKAGLDD 

       430        440 
VLLVAATETT LDIDIPVFAK ALTKVFAQ 

« Hide

References

[1]"The genetic basis of laboratory adaptation in Caulobacter crescentus."
Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1000 / CB15N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001340 Genomic DNA. Translation: ACL96928.1.
RefSeqYP_002518836.1. NC_011916.1.

3D structure databases

ProteinModelPortalB8H4V4.
SMRB8H4V4. Positions 1-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190650.CC_3353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL96928; ACL96928; CCNA_03463.
GeneID7332460.
KEGGccs:CCNA_03463.
PATRIC21311415. VBICauCre52860_3377.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycCAULONA1000:CCNA_03463-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_CAUCN
AccessionPrimary (citable) accession number: B8H4V4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families