B8H4V4 (GCSPA_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	CCNA_03463

Organism

Caulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]

Taxonomic identifier

565050 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter crescentus › Caulobacter crescentus (strain ATCC 19089 / CB15)

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712		PRO_1000147980

Sequences

	Sequence		Length	Mass (Da)
	B8H4V4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: D62740DA0E84303F	FASTA	448	47,298
	10 20 30 40 50 60 MRYLPLTPED RVEMLGAIGV KSIDDLFVDV PVSARRDAPV DLPHHAGELD VEREMAGLAR 70 80 90 100 110 120 RNRAAGEGPF FCGAGAYRHH VPATVDHIIQ RSEFLTSYTP YQPEIAQGTL QVLFEFQTQV 130 140 150 160 170 180 AALTGMEVAN ASLYDGSTGA AEAVMMAQRV TRRNKAVMSG GVHPHYVGAI ETLAHAAGVA 190 200 210 220 230 240 TQALPAAVDA EDAVIAAIDQ DTACVVVQTP NVFGTVTDVS KIAEAAHAAG ALLIVVTTEA 250 260 270 280 290 300 VSFGLLKSPG EMGADIAVAE GQSIGNGLNF GGPYVGLFAC KEKFVRQMPG RLCGETVDAD 310 320 330 340 350 360 GKRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGETGLRQ LAAVNHQKAL 370 380 390 400 410 420 ALRDALKAVP GVEILTPRFF NEFAIRVPGK AAEVVEILAA HGVIAGVPFS RLDAKAGLDD 430 440 VLLVAATETT LDIDIPVFAK ALTKVFAQ

References

[1]

"The genetic basis of laboratory adaptation in Caulobacter crescentus." Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S. J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NA1000 / CB15N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001340 Genomic DNA. Translation: ACL96928.1.
RefSeq	YP_002518836.1. NC_011916.1.
3D structure databases
ProteinModelPortal	B8H4V4.
SMR	B8H4V4. Positions 1-446.
ModBase	Search...
Protein-protein interaction databases
STRING	190650.CC_3353.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL96928; ACL96928; CCNA_03463.
GeneID	7332460.
KEGG	ccs:CCNA_03463.
PATRIC	21311415. VBICauCre52860_3377.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HOG000132025.
KO	K00282.
OMA	MYDGASA.
ProtClustDB	PRK00451.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00712. GcvPA.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
PIRSF	PIRSF006815. GcvPA. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSPA_CAUCN

Accession

Primary (citable) accession number: B8H4V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program