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Protein

Bifunctional protein FolD

Gene

folD

Organism
Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192NADPUniRule annotation1
Binding sitei233NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 169NADPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Oxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolDUniRule annotation
Including the following 2 domains:
Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
Gene namesi
Name:folDUniRule annotation
Ordered Locus Names:CCNA_01275
OrganismiCaulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001856011 – 297Bifunctional protein FolDAdd BLAST297

Proteomic databases

PRIDEiB8H4A3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8H4A3
SMRiB8H4A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218242
KOiK01491
OMAiAGKLCGD
OrthoDBiPOG091H0041

Family and domain databases

HAMAPiMF_01576 THF_DHG_CYH, 1 hit
InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR000672 THF_DH/CycHdrlase
IPR020630 THF_DH/CycHdrlase_cat_dom
IPR020867 THF_DH/CycHdrlase_CS
IPR020631 THF_DH/CycHdrlase_NAD-bd_dom
PANTHERiPTHR10025 PTHR10025, 1 hit
PfamiView protein in Pfam
PF00763 THF_DHG_CYH, 1 hit
PF02882 THF_DHG_CYH_C, 1 hit
PRINTSiPR00085 THFDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00767 THF_DHG_CYH_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8H4A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAKLIDGK AFAADLRAKI AEEVAALKAE HGVTPGLAVV LVGEDPASQV
60 70 80 90 100
YVRNKGEQTT AAGMYSETHR LPETTTQDEL LAVVAKLNAD PKIHGVLVQF
110 120 130 140 150
PVPPHISQMD VVAALSPDKD VDGLTVTNAG RLASGLPALA PCTPTGCMML
160 170 180 190 200
IRDAIGDLKG KTAVVIGRSN LMGKPMAQML LAADCTVTIA HSRSQDLPSI
210 220 230 240 250
VRQADIVVAA VGRAEMVKAD WVKPGAVVID VGITRFPARD PEAAAAGKTR
260 270 280 290
LVGDVAFDEV REVAGAITPV PGGVGPMTIA CLLANTLTAA KRLSGIA
Length:297
Mass (Da):30,685
Last modified:March 3, 2009 - v1
Checksum:iADE986815B50FE13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA Translation: ACL94740.1
RefSeqiWP_012640180.1, NC_011916.1
YP_002516648.1, NC_011916.1

Genome annotation databases

EnsemblBacteriaiACL94740; ACL94740; CCNA_01275
GeneIDi7333005
KEGGiccs:CCNA_01275
PATRICifig|565050.3.peg.1258

Similar proteinsi

Entry informationi

Entry nameiFOLD_CAUVN
AccessioniPrimary (citable) accession number: B8H4A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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