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Protein

Adenine deaminase

Gene

CCNA_03284

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.UniRule annotation

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Zinc; catalyticUniRule annotation
Metal bindingi26 – 261Zinc; catalyticUniRule annotation
Metal bindingi204 – 2041Zinc; catalyticUniRule annotation
Active sitei207 – 2071Proton donorUniRule annotation
Sitei228 – 2281Important for catalytic activityUniRule annotation
Metal bindingi285 – 2851Zinc; catalyticUniRule annotation
Binding sitei286 – 2861SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_03284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
ADEUniRule annotation
Alternative name(s):
Adenine aminohydrolaseUniRule annotation
Short name:
AAHUniRule annotation
Gene namesi
Ordered Locus Names:CCNA_03284
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Adenine deaminasePRO_1000146565Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB8H3Z4.
SMRiB8H3Z4. Positions 13-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.
OrthoDBiEOG6BPDDD.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

B8H3Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDASFAPSA SAEFVRGLPK AELHMHIEGS LEPELMFELA QRNGITLPFA
60 70 80 90 100
SVEEIRAAYD FSNLQDFLDI YYQGAGVLIT EADFKDLALA YFQRLAADGG
110 120 130 140 150
AHAEIFFDPQ THTDRGIAFD TVMNGLLAGM DEAEKTLGVT SKLILCFLRH
160 170 180 190 200
LSEEAAFETL EQAKPWLAKL AGVGLDSSEV GHPPAKFARV LQASRDLGLK
210 220 230 240 250
VVAHAGEEGP PAYVWEAIDL VKVDRIDHGN RALEDEALTA RLVKDGITLT
260 270 280 290 300
VCPLSNLKLC GVPSLDVHPL KRMLDLGLKA TVNSDDPAYF GGYLLENYLA
310 320 330 340
TADAVGLTRD DIVTLAKNSF AGSFLTDAEK AQRIAAVEAY AAAH
Length:344
Mass (Da):37,193
Last modified:March 3, 2009 - v1
Checksum:iDAA5ADE8D796E048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL96748.1.
RefSeqiWP_010921016.1. NC_011916.1.
YP_002518656.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL96748; ACL96748; CCNA_03284.
GeneIDi7330306.
KEGGiccs:CCNA_03284.
PATRICi21311067. VBICauCre52860_3204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL96748.1.
RefSeqiWP_010921016.1. NC_011916.1.
YP_002518656.1. NC_011916.1.

3D structure databases

ProteinModelPortaliB8H3Z4.
SMRiB8H3Z4. Positions 13-320.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL96748; ACL96748; CCNA_03284.
GeneIDi7330306.
KEGGiccs:CCNA_03284.
PATRICi21311067. VBICauCre52860_3204.

Phylogenomic databases

HOGENOMiHOG000218813.
KOiK01488.
OMAiDHGVRAI.
OrthoDBiEOG6BPDDD.

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_03284-MONOMER.

Family and domain databases

HAMAPiMF_01962. Adenine_deaminase.
InterProiIPR001365. A/AMP_deaminase_dom.
IPR028892. ADE.
IPR006330. Ado/ade_deaminase.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01430. aden_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15N.

Entry informationi

Entry nameiADE_CAUCN
AccessioniPrimary (citable) accession number: B8H3Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 11, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.