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B8H3Z4 (ADE_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:CCNA_03284
OrganismCaulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]
Taxonomic identifier565050 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Adenine deaminase HAMAP MF_01962
PRO_1000146565

Sites

Active site2071Proton donor By similarity
Metal binding241Zinc; catalytic By similarity
Metal binding261Zinc; catalytic By similarity
Metal binding2041Zinc; catalytic By similarity
Metal binding2851Zinc; catalytic By similarity
Binding site2861Substrate By similarity
Site2281Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B8H3Z4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: DAA5ADE8D796E048

FASTA34437,193
        10         20         30         40         50         60 
MTDASFAPSA SAEFVRGLPK AELHMHIEGS LEPELMFELA QRNGITLPFA SVEEIRAAYD 

        70         80         90        100        110        120 
FSNLQDFLDI YYQGAGVLIT EADFKDLALA YFQRLAADGG AHAEIFFDPQ THTDRGIAFD 

       130        140        150        160        170        180 
TVMNGLLAGM DEAEKTLGVT SKLILCFLRH LSEEAAFETL EQAKPWLAKL AGVGLDSSEV 

       190        200        210        220        230        240 
GHPPAKFARV LQASRDLGLK VVAHAGEEGP PAYVWEAIDL VKVDRIDHGN RALEDEALTA 

       250        260        270        280        290        300 
RLVKDGITLT VCPLSNLKLC GVPSLDVHPL KRMLDLGLKA TVNSDDPAYF GGYLLENYLA 

       310        320        330        340 
TADAVGLTRD DIVTLAKNSF AGSFLTDAEK AQRIAAVEAY AAAH

« Hide

References

[1]"The genetic basis of laboratory adaptation in Caulobacter crescentus."
Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
J. Bacteriol. 192:3678-3688(2010) [PubMed: 20472802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1000 / CB15N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001340 Genomic DNA. Translation: ACL96748.1.
RefSeqYP_002518656.1. NC_011916.1.

3D structure databases

ProteinModelPortalB8H3Z4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8H3Z4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7330306.
GenomeReviewsGene locus CCNA_03284 in contig CP001340_GR.
KEGGccs:CCNA_03284.
PATRIC21311067. VBICauCre52860_3204.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAFGGYVDD.
PhylomeDBB8H3Z4.
ProtClustDBPRK09358.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_CAUCN
AccessionPrimary (citable) accession number: B8H3Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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