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Protein

Imidazolonepropionase

Gene

hutI

Organism
Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

Cofactori

Zn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 1 zinc or iron ion per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Zinc or ironUniRule annotation1
Metal bindingi72Zinc or ironUniRule annotation1
Binding sitei79SubstrateUniRule annotation1
Binding sitei92SubstrateUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Binding sitei175SubstrateUniRule annotation1
Metal bindingi240Zinc or ironUniRule annotation1
Binding sitei243SubstrateUniRule annotation1
Metal bindingi315Zinc or ironUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00379; UER00551

Protein family/group databases

MEROPSiM38.980

Names & Taxonomyi

Protein namesi
Recommended name:
ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
Alternative name(s):
Imidazolone-5-propionate hydrolaseUniRule annotation
Gene namesi
Name:hutIUniRule annotation
Ordered Locus Names:CCNA_01011
OrganismiCaulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001338821 – 401ImidazolonepropionaseAdd BLAST401

Structurei

3D structure databases

ProteinModelPortaliB8H2S2
SMRiB8H2S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. HutI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218461
KOiK01468
OMAiCMMRAGT
OrthoDBiPOG091H0EIK

Family and domain databases

CDDicd01296 Imidazolone-5PH, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_00372 HutI, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR005920 HutI
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR42752 PTHR42752, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01224 hutI, 1 hit

Sequencei

Sequence statusi: Complete.

B8H2S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCDRVWINA RLATLAPGRQ GLGIVEDGVV ACLGGRIAYA GPAAAAPTFE
60 70 80 90 100
AAESIDVDGR WITPGLIDPH THLVFAGDRA HEFELRLAGA SYEEIARAGG
110 120 130 140 150
GIVSTMRATR AASEAELIAA ALPRLDALLA EGVTTVEIKS GYGLSLDDEL
160 170 180 190 200
KSLRAARALA DIRRVGVTTT FLGAHALPPE YRDDEDGYVD LVCQTMIPAI
210 220 230 240 250
AARGLADAVD GFCEGIGFSP AQIRRVFDAA KAHGLPVKLH AEQLSNLSGA
260 270 280 290 300
ALAAEYNALS ADHLEHLDAA GIAAMAASGT VATLLPGAYY FTRETLVPPI
310 320 330 340 350
AALRAAGVPM ALATDCNPGT SPLTSPLLVM NMAATLFRMT VEECLAGVTR
360 370 380 390 400
EAARALGLLA DRGTLEAGKA CDLAIWDVER PAELVYRMGF NPLHARVWRG

L
Length:401
Mass (Da):42,114
Last modified:March 3, 2009 - v1
Checksum:iEB5FD3FC64B14A84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA Translation: ACL94476.1
RefSeqiWP_010918844.1, NC_011916.1
YP_002516384.1, NC_011916.1

Genome annotation databases

EnsemblBacteriaiACL94476; ACL94476; CCNA_01011
GeneIDi7329759
KEGGiccs:CCNA_01011
PATRICifig|565050.3.peg.993

Similar proteinsi

Entry informationi

Entry nameiHUTI_CAUVN
AccessioniPrimary (citable) accession number: B8H2S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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