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B8H072

- HGD_CAUCN

UniProt

B8H072 - HGD_CAUCN

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei283 – 2831Proton acceptorUniRule annotation
Metal bindingi326 – 3261IronUniRule annotation
Metal bindingi332 – 3321IronUniRule annotation
Binding sitei341 – 3411homogentisateUniRule annotation
Metal bindingi362 – 3621IronUniRule annotation
Binding sitei362 – 3621homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_02615-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:CCNA_02615
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001364: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Homogentisate 1,2-dioxygenasePRO_1000190374Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_2532.

Structurei

3D structure databases

ProteinModelPortaliB8H072.
SMRiB8H072. Positions 2-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

B8H072-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLRYQTGFG SYFETEAHPG ALPVGRNSPQ KVPFGLYAEQ LSGSAFTAPR
60 70 80 90 100
HENRRTWLYR LRPSAGHEAY QPYAQDKLVS AFPGPATPNR LRWSPLEIPA
110 120 130 140 150
APTDFVDGLV SLAGNADAAT LGGIAAHVYL VNVSMKNRVF YNADGEMLIV
160 170 180 190 200
PQMGELTLVT EMGVLKAGPG HIAVIPRGVR FRVEVEGPAR GYVCENYGAA
210 220 230 240 250
FRLPELGPIG ANGLANPRDF EAPVAAFEDI DTPTQVIQKF QGALWAATWD
260 270 280 290 300
HSPLDVVAWH GNLTPYRYDL SRFNTINTVS YDHPDPSIFT VLTSPSDTPG
310 320 330 340 350
TANCDFVIFP PRWMVAEDTF RPPWFHRNVM SEFMGLIHGA YDAKAGGFVP
360 370 380 390 400
GGASLHNCMS DHGPDVASHK KATEVVLAPH KIDGTMAFMF ESRWVFRPTH
410 420
LALESAALQS DYDACWTGFP KARLS
Length:425
Mass (Da):46,607
Last modified:March 3, 2009 - v1
Checksum:iB61AE29016AD9C27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL96080.1.
RefSeqiWP_010920389.1. NC_011916.1.
YP_002517988.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL96080; ACL96080; CCNA_02615.
GeneIDi7332965.
KEGGiccs:CCNA_02615.
PATRICi21309771. VBICauCre52860_2564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL96080.1 .
RefSeqi WP_010920389.1. NC_011916.1.
YP_002517988.1. NC_011916.1.

3D structure databases

ProteinModelPortali B8H072.
SMRi B8H072. Positions 2-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190650.CC_2532.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL96080 ; ACL96080 ; CCNA_02615 .
GeneIDi 7332965.
KEGGi ccs:CCNA_02615.
PATRICi 21309771. VBICauCre52860_2564.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci CAULONA1000:CCNA_02615-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15N.

Entry informationi

Entry nameiHGD_CAUCN
AccessioniPrimary (citable) accession number: B8H072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3