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B8H040 (B8H040_CAUCN) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 1 HAMAP-Rule MF_00421
EC=6.3.5.3 HAMAP-Rule MF_00421
Alternative name(s):
Phosphoribosylformylglycinamidine synthase I HAMAP-Rule MF_00421
Gene names
Name:purQ HAMAP-Rule MF_00421
Ordered Locus Names:CCNA_02583
OrganismCaulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]
Taxonomic identifier565050 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter ›

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00421 SAAS SAAS010075

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00421 SAAS SAAS010075

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00421 SAAS SAAS010075

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00421 SAAS SAAS010075.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00421 SAAS SAAS010075

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain3 – 220218Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00421

Sites

Active site871Nucleophile By similarity HAMAP-Rule MF_00421
Active site1951 By similarity HAMAP-Rule MF_00421

Sequences

Sequence LengthMass (Da)Tools
B8H040 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 0041310F86284C0C

FASTA22023,388
        10         20         30         40         50         60 
MKAAVIVFPG SNCDRDCKVA IERSAGARVE MVWHQETALP DDLDLIVLPG GFSYGDYLRC 

        70         80         90        100        110        120 
GAMAAQSPVM KEVVSAAGKG VAVVGICNGF QVLTEVGLLP GALLRNAGLK YVCKPVELDI 

       130        140        150        160        170        180 
VNGQTRFTAG YGEQRQAVMT VGNGEGNYFA DEETLDRLEG EGQVVFRYKE NPNGSARDIA 

       190        200        210        220 
GIVNKGGNVL GLMPHPDRAF DADLGSEDGA VLFRSIFQSA

« Hide

References

[1]"The genetic basis of laboratory adaptation in Caulobacter crescentus."
Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1000 / CB15N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001340 Genomic DNA. Translation: ACL96048.1.
RefSeqYP_002517956.1. NC_011916.1.

3D structure databases

ProteinModelPortalB8H040.
SMRB8H040. Positions 2-217.
ModBaseSearch...

Protein-protein interaction databases

STRING190650.CC_2497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL96048; ACL96048; CCNA_02583.
GeneID7332933.
KEGGccs:CCNA_02583.
PATRIC21309709. VBICauCre52860_2533.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0047.
HOGENOMHOG000238240.
KOK01952.
OMAFPGTNCD.
ProtClustDBPRK03619.

Enzyme and pathway databases

UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00421. PurQ.
InterProIPR017926. GATASE.
IPR010075. PRibForGlyAmidine_synth_I.
[Graphical view]
PIRSFPIRSF001586. FGAM_synth_I. 1 hit.
TIGRFAMsTIGR01737. FGAM_synth_I. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8H040_CAUCN
AccessionPrimary (citable) accession number: B8H040
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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