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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_00536-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:CCNA_00536
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13561356DNA-directed RNA polymerase subunit betaPRO_1000165797Add
BLAST

Proteomic databases

PRIDEiB8GZW7.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8GZW7.
SMRiB8GZW7. Positions 4-1146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218612.
KOiK03043.
OMAiWWMFAVE.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 5 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GZW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSFTGKKR IRKSFGRIPE AVQMPNLIEV QRSSYEQFLQ RETRPGLRRD
60 70 80 90 100
EGVEAVFKSV FPIKDFNERA VLEYVSYEFE EPKYDVEECI QRDMTFAAPL
110 120 130 140 150
KVKLRLIVFE TEEETGARSV KDIKEQDVYM GDIPLMTDKG TFIVNGTERV
160 170 180 190 200
IVSQMHRSPG VFFDHDKGKT HASGKLLFAA RVIPYRGSWL DFEFDAKDIV
210 220 230 240 250
YVRIDRRRKL PATTFLYALG MDGEEILTTF YDVVPFEKRS GGWATPYKPE
260 270 280 290 300
RWRGVKPEFP LVDADTGEEV APAGTKITAR QAKKFADGGL KTLLLAPEAL
310 320 330 340 350
TGRYLARDAV NMATGEIYAE AGDELDVTSI QALADQGFST IDVLDIDHVT
360 370 380 390 400
VGAYMRNTLR VDKNAIREDA LFDIYRVMRP GEPPTVEAAE AMFKSLFFDA
410 420 430 440 450
ERYDLSSVGR VKMNMRLEQD VSDEVRILRK EDVLAVLKVL VGLRDGRGEI
460 470 480 490 500
DDIDNLGNRR VRSVGELLEN QYRVGLLRME RAIKERMSSV DIDTVMPHDL
510 520 530 540 550
INAKPAAAAV REFFGSSQLS QFMDQTNPLS EITHKRRLSA LGPGGLTRER
560 570 580 590 600
AGFEVRDVHP THYGRICPIE TPEGPNIGLI NSLATHARVN KYGFIESPYR
610 620 630 640 650
RVKDGKPQDE VVYMSAMEES KHVIAQSNIK VAEGEIVEDL VPGRINGEPT
660 670 680 690 700
LLQKETVDLM DVSPRQVVSV AAALIPFLEN DDANRALMGS NMQRQAVPLV
710 720 730 740 750
QSDAPLVGTG MEAVVARDSG AVVIAKRTGV VEQIDGTRIV IRATEETDPA
760 770 780 790 800
RSGVDIYRMS KFQRSNQSTC INQRPLVKVG DRIVAGDIIA DGPSTELGEL
810 820 830 840 850
ALGRNALVAF MPWNGYNFED SILISERIVR DDVFTSIHIE EFEVMARDTK
860 870 880 890 900
LGPEEITRDI PNVGEEALRN LDEAGIVAIG AEVQPGDILV GKVTPKGESP
910 920 930 940 950
MTPEEKLLRA IFGEKASDVR DTSLRLPPGV AGTIVDVRVF NRHGVDKDER
960 970 980 990 1000
ALAIERAEID RLGKDRDDEF AILNRNISGR LKELLIGKVA LSGPKGLSRG
1010 1020 1030 1040 1050
EITAEGLAQV ASGLWWQIAL EDEKAMGELE SLRRLFDENR KRLDRRFEDK
1060 1070 1080 1090 1100
VDKLQRGDEL PPGVMKMVKV FVAVKRKLQP GDKMAGRHGN KGVISRILPI
1110 1120 1130 1140 1150
EDMPFLADGT HVDVVLNPLG VPSRMNVGQI FETHLGWACA NLGKQITNLL
1160 1170 1180 1190 1200
EDWQQGGQKQ ALVERLTEIY GPDEELPDTE EGLVELARNL GKGVPIATPV
1210 1220 1230 1240 1250
FDGARMDDIE GHLEMAGVNK SGQSILFDGL TGEQFKRPVT VGYIYMLKLH
1260 1270 1280 1290 1300
HLVDDKIHAR SIGPYSLVTQ QPLGGKAQFG GQRFGEMEVW ALEAYGAAYT
1310 1320 1330 1340 1350
LQEMLTVKSD DVAGRTKVYE SIVRGDDTFE AGIPESFNVL VKEMRSLGLN

VELENS
Length:1,356
Mass (Da):150,890
Last modified:March 3, 2009 - v1
Checksum:iBA113BA0EB7F6B51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL94001.1.
RefSeqiWP_010918390.1. NC_011916.1.
YP_002515909.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL94001; ACL94001; CCNA_00536.
GeneIDi7332226.
KEGGiccs:CCNA_00536.
PATRICi21305629. VBICauCre52860_0529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL94001.1.
RefSeqiWP_010918390.1. NC_011916.1.
YP_002515909.1. NC_011916.1.

3D structure databases

ProteinModelPortaliB8GZW7.
SMRiB8GZW7. Positions 4-1146.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB8GZW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL94001; ACL94001; CCNA_00536.
GeneIDi7332226.
KEGGiccs:CCNA_00536.
PATRICi21305629. VBICauCre52860_0529.

Phylogenomic databases

HOGENOMiHOG000218612.
KOiK03043.
OMAiWWMFAVE.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_00536-MONOMER.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 5 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15N.

Entry informationi

Entry nameiRPOB_CAUCN
AccessioniPrimary (citable) accession number: B8GZW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 11, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.