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B8GZ33 (MTC1_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase CcrMI

Short name=M.CcrMI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase CcrMI
Gene names
Name:ccrMIM
Synonyms:ccrM
Ordered Locus Names:CCNA_00382
OrganismCaulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]
Taxonomic identifier565050 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Modification methylase CcrMI
PRO_0000378305

Experimental info

Sequence conflict2421Y → D in AAA18913. Ref.1

Sequences

Sequence LengthMass (Da)Tools
B8GZ33 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 05F43266F7D4C614

FASTA35839,665
        10         20         30         40         50         60 
MKFGPETIIH GDCIEQMNAL PEKSVDLIFA DPPYNLQLGG DLLRPDNSKV DAVDDHWDQF 

        70         80         90        100        110        120 
ESFAAYDKFT REWLKAARRV LKDDGAIWVI GSYHNIFRVG VAVQDLGFWI LNDIVWRKSN 

       130        140        150        160        170        180 
PMPNFKGTRF ANAHETLIWA SKSQNAKRYT FNYDALKMAN DEVQMRSDWT IPLCTGEERI 

       190        200        210        220        230        240 
KGADGQKAHP TQKPEALLYR VILSTTKPGD VILDPFFGVG TTGAAAKRLG RKFIGIEREA 

       250        260        270        280        290        300 
EYLEHAKARI AKVVPIAPED LDVMGSKRAE PRVPFGTIVE AGLLSPGDTL YCSKGTHVAK 

       310        320        330        340        350 
VRPDGSITVG DLSGSIHKIG ALVQSAPACN GWTYWHFKTD AGLAPIDVLR AQVRAGMN 

« Hide

References

« Hide 'large scale' references
[1]"A Caulobacter DNA methyltransferase that functions only in the predivisional cell."
Zweiger G., Marczynski G., Shapiro L.
J. Mol. Biol. 235:472-485(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genetic basis of laboratory adaptation in Caulobacter crescentus."
Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1000 / CB15N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01032 Unassigned DNA. Translation: AAA18913.1.
CP001340 Genomic DNA. Translation: ACL93849.1.
PIRS43876.
RefSeqYP_002515757.1. NC_011916.1.

3D structure databases

ProteinModelPortalB8GZ33.
SMRB8GZ33. Positions 12-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190650.CC_0378.

Protein family/group databases

REBASE19987. M.CcrNAI.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL93849; ACL93849; CCNA_00382.
GeneID7331081.
KEGGccs:CCNA_00382.
PATRIC21305331. VBICauCre52860_0381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0863.
HOGENOMHOG000125329.
KOK13581.
OMAFWHFEDG.
OrthoDBEOG6FV84T.
ProtClustDBCLSK889886.

Enzyme and pathway databases

BioCycCAULONA1000:CCNA_00382-MONOMER.

Family and domain databases

InterProIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTC1_CAUCN
AccessionPrimary (citable) accession number: B8GZ33
Secondary accession number(s): Q45971
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries