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Protein

Modification methylase CcrMI

Gene

ccrMIM

Organism
Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology.

Catalytic activityi

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processDNA replication
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi19987 M.CcrNAI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase CcrMI (EC:2.1.1.72)
Short name:
M.CcrMI
Alternative name(s):
Adenine-specific methyltransferase CcrMI
Gene namesi
Name:ccrMIM
Synonyms:ccrM
Ordered Locus Names:CCNA_00382
OrganismiCaulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003783051 – 358Modification methylase CcrMIAdd BLAST358

Proteomic databases

PRIDEiB8GZ33

Structurei

3D structure databases

ProteinModelPortaliB8GZ33
SMRiB8GZ33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

HOGENOMiHOG000125329
KOiK13581
OMAiWDKFSSF
OrthoDBiPOG091H00H5

Family and domain databases

InterProiView protein in InterPro
IPR002941 DNA_methylase_N4/N6
IPR002052 DNA_methylase_N6_adenine_CS
IPR001091 RM_Methylase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01555 N6_N4_Mtase, 1 hit
PRINTSiPR00508 S21N4MTFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

B8GZ33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGPETIIH GDCIEQMNAL PEKSVDLIFA DPPYNLQLGG DLLRPDNSKV
60 70 80 90 100
DAVDDHWDQF ESFAAYDKFT REWLKAARRV LKDDGAIWVI GSYHNIFRVG
110 120 130 140 150
VAVQDLGFWI LNDIVWRKSN PMPNFKGTRF ANAHETLIWA SKSQNAKRYT
160 170 180 190 200
FNYDALKMAN DEVQMRSDWT IPLCTGEERI KGADGQKAHP TQKPEALLYR
210 220 230 240 250
VILSTTKPGD VILDPFFGVG TTGAAAKRLG RKFIGIEREA EYLEHAKARI
260 270 280 290 300
AKVVPIAPED LDVMGSKRAE PRVPFGTIVE AGLLSPGDTL YCSKGTHVAK
310 320 330 340 350
VRPDGSITVG DLSGSIHKIG ALVQSAPACN GWTYWHFKTD AGLAPIDVLR

AQVRAGMN
Length:358
Mass (Da):39,665
Last modified:March 3, 2009 - v1
Checksum:i05F43266F7D4C614
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242Y → D in AAA18913 (PubMed:8289276).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01032 Unassigned DNA Translation: AAA18913.1
CP001340 Genomic DNA Translation: ACL93849.1
PIRiS43876
RefSeqiWP_010918266.1, NC_011916.1
YP_002515757.1, NC_011916.1

Genome annotation databases

EnsemblBacteriaiACL93849; ACL93849; CCNA_00382
GeneIDi7331081
KEGGiccs:CCNA_00382
PATRICifig|565050.3.peg.381

Similar proteinsi

Entry informationi

Entry nameiMTC1_CAUVN
AccessioniPrimary (citable) accession number: B8GZ33
Secondary accession number(s): Q45971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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