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B8GZ33

- MTC1_CAUCN

UniProt

B8GZ33 - MTC1_CAUCN

Protein

Modification methylase CcrMI

Gene

ccrMIM

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. Ccrm-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCAULONA1000:CCNA_00382-MONOMER.

    Protein family/group databases

    REBASEi19987. M.CcrNAI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase CcrMI (EC:2.1.1.72)
    Short name:
    M.CcrMI
    Alternative name(s):
    Adenine-specific methyltransferase CcrMI
    Gene namesi
    Name:ccrMIM
    Synonyms:ccrM
    Ordered Locus Names:CCNA_00382
    OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
    Taxonomic identifieri565050 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001364: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Modification methylase CcrMIPRO_0000378305Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190650.CC_0378.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GZ33.
    SMRiB8GZ33. Positions 12-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0863.
    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiFWHFEDG.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8GZ33-1 [UniParc]FASTAAdd to Basket

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    MKFGPETIIH GDCIEQMNAL PEKSVDLIFA DPPYNLQLGG DLLRPDNSKV    50
    DAVDDHWDQF ESFAAYDKFT REWLKAARRV LKDDGAIWVI GSYHNIFRVG 100
    VAVQDLGFWI LNDIVWRKSN PMPNFKGTRF ANAHETLIWA SKSQNAKRYT 150
    FNYDALKMAN DEVQMRSDWT IPLCTGEERI KGADGQKAHP TQKPEALLYR 200
    VILSTTKPGD VILDPFFGVG TTGAAAKRLG RKFIGIEREA EYLEHAKARI 250
    AKVVPIAPED LDVMGSKRAE PRVPFGTIVE AGLLSPGDTL YCSKGTHVAK 300
    VRPDGSITVG DLSGSIHKIG ALVQSAPACN GWTYWHFKTD AGLAPIDVLR 350
    AQVRAGMN 358
    Length:358
    Mass (Da):39,665
    Last modified:March 3, 2009 - v1
    Checksum:i05F43266F7D4C614
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421Y → D in AAA18913. (PubMed:8289276)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01032 Unassigned DNA. Translation: AAA18913.1.
    CP001340 Genomic DNA. Translation: ACL93849.1.
    PIRiS43876.
    RefSeqiYP_002515757.1. NC_011916.1.

    Genome annotation databases

    EnsemblBacteriaiACL93849; ACL93849; CCNA_00382.
    GeneIDi7331081.
    KEGGiccs:CCNA_00382.
    PATRICi21305331. VBICauCre52860_0381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U01032 Unassigned DNA. Translation: AAA18913.1 .
    CP001340 Genomic DNA. Translation: ACL93849.1 .
    PIRi S43876.
    RefSeqi YP_002515757.1. NC_011916.1.

    3D structure databases

    ProteinModelPortali B8GZ33.
    SMRi B8GZ33. Positions 12-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190650.CC_0378.

    Protein family/group databases

    REBASEi 19987. M.CcrNAI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL93849 ; ACL93849 ; CCNA_00382 .
    GeneIDi 7331081.
    KEGGi ccs:CCNA_00382.
    PATRICi 21305331. VBICauCre52860_0381.

    Phylogenomic databases

    eggNOGi COG0863.
    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi FWHFEDG.
    OrthoDBi EOG6FV84T.

    Enzyme and pathway databases

    BioCyci CAULONA1000:CCNA_00382-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A Caulobacter DNA methyltransferase that functions only in the predivisional cell."
      Zweiger G., Marczynski G., Shapiro L.
      J. Mol. Biol. 235:472-485(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
      Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
      J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1000 / CB15N.

    Entry informationi

    Entry nameiMTC1_CAUCN
    AccessioniPrimary (citable) accession number: B8GZ33
    Secondary accession number(s): Q45971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3