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B8GYE8 (GLSA_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase

EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:CCNA_00278
OrganismCaulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]
Taxonomic identifier565050 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Glutaminase HAMAP-Rule MF_00313
PRO_1000132903

Sites

Binding site661Substrate By similarity
Binding site1161Substrate By similarity
Binding site1591Substrate By similarity
Binding site1661Substrate By similarity
Binding site1901Substrate By similarity
Binding site2421Substrate By similarity
Binding site2601Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B8GYE8 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 5B550D1025EC40DF

FASTA30632,286
        10         20         30         40         50         60 
MKALSIPDVL AEVAVLVRPH FGKGKPADYI PQLATVPGGK FGMAVRMVDG DEHVIGDADE 

        70         80         90        100        110        120 
GFSVQSITKV FALGLALNRL GDEIWTRVGK EPSGTPFNHL SLLEAEQGVP RNPFINAGAL 

       130        140        150        160        170        180 
AVTDVLMDVT RDPAALVRDF GGFLCGERLE IDPAVATSEL AHAWQNRAIA SLMRAKGTIT 

       190        200        210        220        230        240 
HDPEAVVAAY CRQCALSMSC RQLARAFLPL AAGGFSPIAQ ETVFPERLTR RLNALLLTCG 

       250        260        270        280        290        300 
IYDSVGSFAY RVGLPAKSGV GGGIVAVVPG KATVAVWSPE LDRFGTSVVG TAALEAFSQI 


TNCSVL 

« Hide

References

[1]"The genetic basis of laboratory adaptation in Caulobacter crescentus."
Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1000 / CB15N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001340 Genomic DNA. Translation: ACL93745.1.
RefSeqYP_002515653.1. NC_011916.1.

3D structure databases

ProteinModelPortalB8GYE8.
SMRB8GYE8. Positions 24-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190650.CC_0276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL93745; ACL93745; CCNA_00278.
GeneID7330731.
KEGGccs:CCNA_00278.
PATRIC21305119. VBICauCre52860_0275.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAQRARRIN.
OrthoDBEOG6N94BK.

Enzyme and pathway databases

BioCycCAULONA1000:CCNA_00278-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_CAUCN
AccessionPrimary (citable) accession number: B8GYE8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families