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B8GYE8

- GLSA_CAUCN

UniProt

B8GYE8 - GLSA_CAUCN

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Protein
Glutaminase
Gene
glsA, CCNA_00278
Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Binding sitei159 – 1591Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei242 – 2421Substrate By similarity
Binding sitei260 – 2601Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_00278-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:CCNA_00278
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001364: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306GlutaminaseUniRule annotation
PRO_1000132903Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi190650.CC_0276.

Structurei

3D structure databases

ProteinModelPortaliB8GYE8.
SMRiB8GYE8. Positions 24-290.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GYE8-1 [UniParc]FASTAAdd to Basket

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MKALSIPDVL AEVAVLVRPH FGKGKPADYI PQLATVPGGK FGMAVRMVDG    50
DEHVIGDADE GFSVQSITKV FALGLALNRL GDEIWTRVGK EPSGTPFNHL 100
SLLEAEQGVP RNPFINAGAL AVTDVLMDVT RDPAALVRDF GGFLCGERLE 150
IDPAVATSEL AHAWQNRAIA SLMRAKGTIT HDPEAVVAAY CRQCALSMSC 200
RQLARAFLPL AAGGFSPIAQ ETVFPERLTR RLNALLLTCG IYDSVGSFAY 250
RVGLPAKSGV GGGIVAVVPG KATVAVWSPE LDRFGTSVVG TAALEAFSQI 300
TNCSVL 306
Length:306
Mass (Da):32,286
Last modified:March 3, 2009 - v1
Checksum:i5B550D1025EC40DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001340 Genomic DNA. Translation: ACL93745.1.
RefSeqiWP_010918165.1. NC_011916.1.
YP_002515653.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL93745; ACL93745; CCNA_00278.
GeneIDi7330731.
KEGGiccs:CCNA_00278.
PATRICi21305119. VBICauCre52860_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001340 Genomic DNA. Translation: ACL93745.1 .
RefSeqi WP_010918165.1. NC_011916.1.
YP_002515653.1. NC_011916.1.

3D structure databases

ProteinModelPortali B8GYE8.
SMRi B8GYE8. Positions 24-290.
ModBasei Search...

Protein-protein interaction databases

STRINGi 190650.CC_0276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL93745 ; ACL93745 ; CCNA_00278 .
GeneIDi 7330731.
KEGGi ccs:CCNA_00278.
PATRICi 21305119. VBICauCre52860_0275.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci CAULONA1000:CCNA_00278-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15N.

Entry informationi

Entry nameiGLSA_CAUCN
AccessioniPrimary (citable) accession number: B8GYE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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