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B8GYE8

- GLSA_CAUCN

UniProt

B8GYE8 - GLSA_CAUCN

Protein

Glutaminase

Gene

glsA

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661SubstrateUniRule annotation
    Binding sitei116 – 1161SubstrateUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Binding sitei190 – 1901SubstrateUniRule annotation
    Binding sitei242 – 2421SubstrateUniRule annotation
    Binding sitei260 – 2601Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCAULONA1000:CCNA_00278-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:CCNA_00278
    OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
    Taxonomic identifieri565050 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001364: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306GlutaminasePRO_1000132903Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi190650.CC_0276.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GYE8.
    SMRiB8GYE8. Positions 24-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQRARRIN.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8GYE8-1 [UniParc]FASTAAdd to Basket

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    MKALSIPDVL AEVAVLVRPH FGKGKPADYI PQLATVPGGK FGMAVRMVDG    50
    DEHVIGDADE GFSVQSITKV FALGLALNRL GDEIWTRVGK EPSGTPFNHL 100
    SLLEAEQGVP RNPFINAGAL AVTDVLMDVT RDPAALVRDF GGFLCGERLE 150
    IDPAVATSEL AHAWQNRAIA SLMRAKGTIT HDPEAVVAAY CRQCALSMSC 200
    RQLARAFLPL AAGGFSPIAQ ETVFPERLTR RLNALLLTCG IYDSVGSFAY 250
    RVGLPAKSGV GGGIVAVVPG KATVAVWSPE LDRFGTSVVG TAALEAFSQI 300
    TNCSVL 306
    Length:306
    Mass (Da):32,286
    Last modified:March 3, 2009 - v1
    Checksum:i5B550D1025EC40DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL93745.1.
    RefSeqiWP_010918165.1. NC_011916.1.
    YP_002515653.1. NC_011916.1.

    Genome annotation databases

    EnsemblBacteriaiACL93745; ACL93745; CCNA_00278.
    GeneIDi7330731.
    KEGGiccs:CCNA_00278.
    PATRICi21305119. VBICauCre52860_0275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL93745.1 .
    RefSeqi WP_010918165.1. NC_011916.1.
    YP_002515653.1. NC_011916.1.

    3D structure databases

    ProteinModelPortali B8GYE8.
    SMRi B8GYE8. Positions 24-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190650.CC_0276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL93745 ; ACL93745 ; CCNA_00278 .
    GeneIDi 7330731.
    KEGGi ccs:CCNA_00278.
    PATRICi 21305119. VBICauCre52860_0275.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QRARRIN.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci CAULONA1000:CCNA_00278-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
      Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
      J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1000 / CB15N.

    Entry informationi

    Entry nameiGLSA_CAUCN
    AccessioniPrimary (citable) accession number: B8GYE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3