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Protein

Ribonuclease PH

Gene

rph

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.By similarity

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_00151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PH (EC:2.7.7.56)
Short name:
RNase PH
Alternative name(s):
tRNA nucleotidyltransferase
Gene namesi
Name:rph
Ordered Locus Names:CCNA_00151
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003783081 – 238Ribonuclease PHAdd BLAST238

Structurei

3D structure databases

ProteinModelPortaliB8GXP2.
SMRiB8GXP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

HOGENOMiHOG000229516.
KOiK00989.
OMAiKGKGQGW.
OrthoDBiPOG091H03ML.

Family and domain databases

CDDicd11362. RNase_PH_bact. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GXP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSERAPDQ LRAVTLETGV NRYAEGSCLI GFGHTKVLVT ATVEENVPGW
60 70 80 90 100
MRNKGAGWVT AEYGMLPRAT HTRGRREAAA GKQTGRTQEI QRLIGRSLRA
110 120 130 140 150
VVDLKALGER QITLDCDVVQ ADGGTRTAAI TGAWVALRLA TKYLLDEGVL
160 170 180 190 200
KTDPILGQVA AVSCGVFNGV PVLDLDYEED SNAEADSNFV LTGVGDIVEI
210 220 230
QATGEKRGFT RAEFESLYGL AEKGINELFA LQRAAIGG
Length:238
Mass (Da):25,549
Last modified:March 3, 2009 - v1
Checksum:i8DC29753AD7EFE58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 28EGSC → RAL in AAB01514 (PubMed:8606155).Curated4
Sequence conflicti206K → T in AAB01514 (PubMed:8606155).Curated1
Sequence conflicti220 – 234LAEKG…ALQRA → AGREGVQRTVRLLARL in AAB01514 (PubMed:8606155).CuratedAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33324 Genomic DNA. Translation: AAB01514.1.
CP001340 Genomic DNA. Translation: ACL93618.1.
RefSeqiWP_010918041.1. NC_011916.1.
YP_002515526.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL93618; ACL93618; CCNA_00151.
GeneIDi7332405.
KEGGiccs:CCNA_00151.
PATRICi21304867. VBICauCre52860_0150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33324 Genomic DNA. Translation: AAB01514.1.
CP001340 Genomic DNA. Translation: ACL93618.1.
RefSeqiWP_010918041.1. NC_011916.1.
YP_002515526.1. NC_011916.1.

3D structure databases

ProteinModelPortaliB8GXP2.
SMRiB8GXP2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL93618; ACL93618; CCNA_00151.
GeneIDi7332405.
KEGGiccs:CCNA_00151.
PATRICi21304867. VBICauCre52860_0150.

Phylogenomic databases

HOGENOMiHOG000229516.
KOiK00989.
OMAiKGKGQGW.
OrthoDBiPOG091H03ML.

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_00151-MONOMER.

Family and domain databases

CDDicd11362. RNase_PH_bact. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNPH_CAUCN
AccessioniPrimary (citable) accession number: B8GXP2
Secondary accession number(s): P48196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.