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B8GX04

- TRMB_CAUCN

UniProt

B8GX04 - TRMB_CAUCN

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei59 – 591S-adenosyl-L-methionineUniRule annotation
    Binding sitei84 – 841S-adenosyl-L-methionineUniRule annotation
    Binding sitei111 – 1111S-adenosyl-L-methionineUniRule annotation
    Active sitei133 – 1331By similarity
    Binding sitei133 – 1331S-adenosyl-L-methionineUniRule annotation
    Binding sitei137 – 1371SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCAULONA1000:CCNA_00047-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:CCNA_00047
    OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
    Taxonomic identifieri565050 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001364: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226tRNA (guanine-N(7)-)-methyltransferasePRO_1000149650Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi190650.CC_0049.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GX04.
    SMRiB8GX04. Positions 56-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1446Interaction with RNAUniRule annotation
    Regioni206 – 2094Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiYLTFIKK.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8GX04-1 [UniParc]FASTAAdd to Basket

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    MTTPQQPHGP LRSFGRLKSR PVKPRQQALL DTLLPEIAVP TGPFQPLDLM    50
    PEAKAVWLEI GFGGGEHMAS QAGRNPETLV IGAEPFVNGV ASAVRHVEEQ 100
    ALKNVRIHEG DARDVVDWLP DACLDRVFIM FPDPWHKARH NKRRLIQPEF 150
    VAKLARVMKP GAALRFATDW ADYAEWTTER VLADPSFRFA DEAADRNAIP 200
    ADHVTTRYEE KKLGDCAPVF LDFTRG 226
    Length:226
    Mass (Da):25,322
    Last modified:March 3, 2009 - v1
    Checksum:i6575F723126A1032
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL93514.1.
    RefSeqiWP_012639863.1. NC_011916.1.
    YP_002515422.1. NC_011916.1.

    Genome annotation databases

    EnsemblBacteriaiACL93514; ACL93514; CCNA_00047.
    GeneIDi7332137.
    KEGGiccs:CCNA_00047.
    PATRICi21304659. VBICauCre52860_0047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL93514.1 .
    RefSeqi WP_012639863.1. NC_011916.1.
    YP_002515422.1. NC_011916.1.

    3D structure databases

    ProteinModelPortali B8GX04.
    SMRi B8GX04. Positions 56-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190650.CC_0049.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL93514 ; ACL93514 ; CCNA_00047 .
    GeneIDi 7332137.
    KEGGi ccs:CCNA_00047.
    PATRICi 21304659. VBICauCre52860_0047.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi YLTFIKK.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CAULONA1000:CCNA_00047-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
      Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
      J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1000 / CB15N.

    Entry informationi

    Entry nameiTRMB_CAUCN
    AccessioniPrimary (citable) accession number: B8GX04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3