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B8GX04

- TRMB_CAUCN

UniProt

B8GX04 - TRMB_CAUCN

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, CCNA_00047
Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591S-adenosyl-L-methionine By similarity
Binding sitei84 – 841S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111S-adenosyl-L-methionine By similarity
Active sitei133 – 1331 By similarity
Binding sitei133 – 1331S-adenosyl-L-methionine By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei169 – 1691Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_00047-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:CCNA_00047
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001364: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000149650Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_0049.

Structurei

3D structure databases

ProteinModelPortaliB8GX04.
SMRiB8GX04. Positions 56-211.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 1446Interaction with RNA Reviewed prediction
Regioni206 – 2094Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiYLTFIKK.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GX04-1 [UniParc]FASTAAdd to Basket

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MTTPQQPHGP LRSFGRLKSR PVKPRQQALL DTLLPEIAVP TGPFQPLDLM    50
PEAKAVWLEI GFGGGEHMAS QAGRNPETLV IGAEPFVNGV ASAVRHVEEQ 100
ALKNVRIHEG DARDVVDWLP DACLDRVFIM FPDPWHKARH NKRRLIQPEF 150
VAKLARVMKP GAALRFATDW ADYAEWTTER VLADPSFRFA DEAADRNAIP 200
ADHVTTRYEE KKLGDCAPVF LDFTRG 226
Length:226
Mass (Da):25,322
Last modified:March 3, 2009 - v1
Checksum:i6575F723126A1032
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001340 Genomic DNA. Translation: ACL93514.1.
RefSeqiWP_012639863.1. NC_011916.1.
YP_002515422.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL93514; ACL93514; CCNA_00047.
GeneIDi7332137.
KEGGiccs:CCNA_00047.
PATRICi21304659. VBICauCre52860_0047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001340 Genomic DNA. Translation: ACL93514.1 .
RefSeqi WP_012639863.1. NC_011916.1.
YP_002515422.1. NC_011916.1.

3D structure databases

ProteinModelPortali B8GX04.
SMRi B8GX04. Positions 56-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190650.CC_0049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL93514 ; ACL93514 ; CCNA_00047 .
GeneIDi 7332137.
KEGGi ccs:CCNA_00047.
PATRICi 21304659. VBICauCre52860_0047.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi YLTFIKK.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CAULONA1000:CCNA_00047-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15N.

Entry informationi

Entry nameiTRMB_CAUCN
AccessioniPrimary (citable) accession number: B8GX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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