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Protein

Peptide chain release factor 2

Gene

prfB

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_01950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 2UniRule annotation
Short name:
RF-2UniRule annotation
Gene namesi
Name:prfBUniRule annotation
Ordered Locus Names:CCNA_01950
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Peptide chain release factor 2PRO_1000193548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei247 – 2471N5-methylglutamineUniRule annotation

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF2.UniRule annotation

Keywords - PTMi

Methylation

Structurei

3D structure databases

ProteinModelPortaliB8GWM3.
SMRiB8GWM3. Positions 14-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000074814.
KOiK02836.
OMAiRLYEHEM.
OrthoDBiPOG091H027X.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00094. Rel_fac_2. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR020853. Peptide_chain_release_fac2_bac.
IPR004374. PrfB.
[Graphical view]
PANTHERiPTHR11075:SF6. PTHR11075:SF6. 1 hit.
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00020. prfB. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GWM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPLRPTSS SPWDCSGGVF DWDVALRKLD ELNARVEDPT LWDRPSEAQA
60 70 80 90 100
VSRERANLAA KVEAVQSIER DLKDALEYAE LAEMESDEDS LNDARAQLKS
110 120 130 140 150
LKERAGRAEL EALLSGEADG NDCYVEINSG AGGTESCDWA GILLRMYTRW
160 170 180 190 200
ANAHGMTTEL IEETDGDQAG IKSATLLVKG ANAYGWLKTE AGVHRLVRIS
210 220 230 240 250
PYDSSARRHT SFASAWVYPV VDDNIEIEIN PSDVRTDTYR ASGAGGQHIN
260 270 280 290 300
KTDSAVRLTH IPTGIAVACQ AGRSQHQNRE EAWKMLRARL YEAELQKREA
310 320 330 340 350
AQQALEDQKT DIGWGHQIRS YVLQPYQMVK DLRTNVETSD TQGVLDGDLD
360 370
AFMAASLAQR VGHTRDGGEA S
Length:371
Mass (Da):40,922
Last modified:March 3, 2009 - v1
Checksum:iF66090AC5D3FEB44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL95415.1.
RefSeqiWP_010919740.1. NC_011916.1.
YP_002517323.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL95415; ACL95415; CCNA_01950.
GeneIDi7330090.
KEGGiccs:CCNA_01950.
PATRICi21308435. VBICauCre52860_1910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL95415.1.
RefSeqiWP_010919740.1. NC_011916.1.
YP_002517323.1. NC_011916.1.

3D structure databases

ProteinModelPortaliB8GWM3.
SMRiB8GWM3. Positions 14-357.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL95415; ACL95415; CCNA_01950.
GeneIDi7330090.
KEGGiccs:CCNA_01950.
PATRICi21308435. VBICauCre52860_1910.

Phylogenomic databases

HOGENOMiHOG000074814.
KOiK02836.
OMAiRLYEHEM.
OrthoDBiPOG091H027X.

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_01950-MONOMER.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00094. Rel_fac_2. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR020853. Peptide_chain_release_fac2_bac.
IPR004374. PrfB.
[Graphical view]
PANTHERiPTHR11075:SF6. PTHR11075:SF6. 1 hit.
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00020. prfB. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRF2_CAUCN
AccessioniPrimary (citable) accession number: B8GWM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.