prfB

Functionⁱ

Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.UniRule annotation

GO - Molecular functionⁱ

translation release factor activity, codon specific Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein biosynthesis

Biological process

Protein biosynthesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptide chain release factor 2UniRule annotation Short name: RF-2UniRule annotation
Gene namesⁱ	Name:prfBUniRule annotation Ordered Locus Names:CCNA_01950
Organismⁱ	Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Taxonomic identifierⁱ	565050 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter › Caulobacter vibrioides ›
Proteomesⁱ	UP000001364 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00094

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000193548	1 – 371	Peptide chain release factor 2Add BLAST		371

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	247	N5-methylglutamineUniRule annotation		1

Post-translational modificationⁱ

Methylated by PrmC. Methylation increases the termination efficiency of RF2.UniRule annotation

Keywords - PTMⁱ

Methylation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B8GWM3.
SMRⁱ	B8GWM3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000074814.
KEGG Orthology (KO) More...KOⁱ	K02836.
OMAⁱ	YVFHPYQ.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H027X.

Family and domain databases

HAMAPⁱ	MF_00094. Rel_fac_2. 1 hit.
InterProⁱ	View protein in InterPro IPR005139. PCRF. IPR000352. Pep_chain_release_fac_I_II. IPR004374. PrfB.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03462. PCRF. 1 hit. PF00472. RF-1. 1 hit.
SMARTⁱ	View protein in SMART SM00937. PCRF. 1 hit.
TIGRFAMsⁱ	TIGR00020. prfB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00745. RF_PROK_I. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B8GWM3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRPLRPTSS SPWDCSGGVF DWDVALRKLD ELNARVEDPT LWDRPSEAQA 
        60         70         80         90        100
VSRERANLAA KVEAVQSIER DLKDALEYAE LAEMESDEDS LNDARAQLKS 
       110        120        130        140        150
LKERAGRAEL EALLSGEADG NDCYVEINSG AGGTESCDWA GILLRMYTRW 
       160        170        180        190        200
ANAHGMTTEL IEETDGDQAG IKSATLLVKG ANAYGWLKTE AGVHRLVRIS 
       210        220        230        240        250
PYDSSARRHT SFASAWVYPV VDDNIEIEIN PSDVRTDTYR ASGAGGQHIN 
       260        270        280        290        300
KTDSAVRLTH IPTGIAVACQ AGRSQHQNRE EAWKMLRARL YEAELQKREA 
       310        320        330        340        350
AQQALEDQKT DIGWGHQIRS YVLQPYQMVK DLRTNVETSD TQGVLDGDLD 
       360        370 
AFMAASLAQR VGHTRDGGEA S

Length:371

Mass (Da):40,922

Last modified:March 3, 2009 - v1

Checksum:ⁱF66090AC5D3FEB44

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001340 Genomic DNA. Translation: ACL95415.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010919740.1. NC_011916.1. YP_002517323.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACL95415; ACL95415; CCNA_01950.
GeneIDⁱ	7330090.
KEGGⁱ	ccs:CCNA_01950.
PATRICⁱ	fig\|565050.3.peg.1910.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B8GWM3	Q9A752	Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)	371	UniRef100_Q9A752	Cluster: Peptide chain release factor 2	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B8GWM3	Q9A752 A0A2G5RAT4 A0A290MPV4 UPI000324D116 A0A2G5QNG5 A0A2G5RC55 D5VJU9 A0A2G4KET6 UPI000C784C24 UPI000C78B340 +9	Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) Caulobacter sp. FWC26 Caulobacter vibrioides (Caulobacter crescentus) Caulobacter sp. FWC2 Caulobacter sp. X Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis) Caulobacter sp. BP25 Caulobacter sp. 410 Caulobacter flavus Caulobacter henricii And more	371	UniRef90_Q9A752	Cluster: Peptide chain release factor 2	20

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B8GWM3	Q9A752 UPI000324D116 A0A2G5RAT4 A0A290MPV4 A0A2G5RC55 UPI000C78B340 A0A2G5QNG5 UPI000C784C24 D5VJU9 A0A2G4KET6 +1284	Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) Caulobacter vibrioides (Caulobacter crescentus) Caulobacter sp. FWC26 Caulobacter sp. X Caulobacter flavus Caulobacter sp. FWC2 Caulobacter sp. 410 Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / NBRC 15250 / LMG 17158 / TK0059) (Mycoplana segnis) Caulobacter sp. BP25 Caulobacter henricii And more	371	UniRef50_Q9A752	Cluster: Peptide chain release factor 2	1,295

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001340 Genomic DNA. Translation: ACL95415.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010919740.1. NC_011916.1. YP_002517323.1. NC_011916.1.

3D structure databases

ProteinModelPortalⁱ	B8GWM3.
SMRⁱ	B8GWM3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACL95415; ACL95415; CCNA_01950.
GeneIDⁱ	7330090.
KEGGⁱ	ccs:CCNA_01950.
PATRICⁱ	fig\|565050.3.peg.1910.

Phylogenomic databases

HOGENOMⁱ	HOG000074814.
KEGG Orthology (KO) More...KOⁱ	K02836.
OMAⁱ	YVFHPYQ.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H027X.

Family and domain databases

HAMAPⁱ	MF_00094. Rel_fac_2. 1 hit.
InterProⁱ	View protein in InterPro IPR005139. PCRF. IPR000352. Pep_chain_release_fac_I_II. IPR004374. PrfB.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03462. PCRF. 1 hit. PF00472. RF-1. 1 hit.
SMARTⁱ	View protein in SMART SM00937. PCRF. 1 hit.
TIGRFAMsⁱ	TIGR00020. prfB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00745. RF_PROK_I. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RF2_CAUVN
Accessionⁱ	B8GWM3Primary (citable) accession number: B8GWM3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
	Last sequence update:	March 3, 2009
	Last modified:	March 28, 2018
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB - B8GWM3 (RF2_CAUVN)

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Peptide chain release factor 2

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Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Post-translational modificationⁱ

Keywords - PTMⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B8GWM3 (RF2_CAUVN)

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Peptide chain release factor 2

prfB

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ