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B8GW76

- B8GW76_CAUCN

UniProt

B8GW76 - B8GW76_CAUCN

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

CCNA_01803

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciCAULONA1000:CCNA_01803-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:CCNA_01803Imported
    OrganismiCaulobacter crescentus (strain NA1000 / CB15N)Imported
    Taxonomic identifieri565050 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001364: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi190650.CC_1729.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GW76.
    SMRiB8GW76. Positions 5-68, 123-160, 197-428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281566.
    KOiK00627.
    OMAiVESCIIT.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8GW76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIDILMPAL SPTMEEGTLA KWHVKVGDTV KAGDVIAEIE TDKATMEVEA    50
    VDEGVVEAIL VPAGTENVKV NALIAKLAGE GDSPAPAPKV EAPKAAAAAP 100
    VPAAAPAPAV PAPAAPVAAD GSRVLASPLA RRLASAAGLD LKALKGTGPH 150
    GRVVKSDVEA AKSGAPAAKA APASAPAAVA PTAAAPRQIQ SLEQMGIPAG 200
    SYDLVPLDGM RKTIARRMTE SFRDVPHFPL TIDLEIDALL AARAKINSLL 250
    EKQGVKVSVN DIVIKAAAVA LKQVPEANAS YTPEGIAMHH HADIAVAVAV 300
    DGGLITPIIR KAETKGLAQI SAEMKDLAQR AKDKKLKPEE FQGGTFSISN 350
    LGMFGIKSFA SIINEPQGAI MSVGAGEQRP VVKNGEIKVA TVMTVTLTCD 400
    HRVVDGSVGA KFLAAFRPLI EEPLTLIV 428
    Length:428
    Mass (Da):44,011
    Last modified:March 3, 2009 - v1
    Checksum:iA8234BA3B8D6B1B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL95268.1.
    RefSeqiWP_010919597.1. NC_011916.1.
    YP_002517176.1. NC_011916.1.

    Genome annotation databases

    EnsemblBacteriaiACL95268; ACL95268; CCNA_01803.
    GeneIDi7331269.
    KEGGiccs:CCNA_01803.
    PATRICi21308157. VBICauCre52860_1772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001340 Genomic DNA. Translation: ACL95268.1 .
    RefSeqi WP_010919597.1. NC_011916.1.
    YP_002517176.1. NC_011916.1.

    3D structure databases

    ProteinModelPortali B8GW76.
    SMRi B8GW76. Positions 5-68, 123-160, 197-428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 190650.CC_1729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL95268 ; ACL95268 ; CCNA_01803 .
    GeneIDi 7331269.
    KEGGi ccs:CCNA_01803.
    PATRICi 21308157. VBICauCre52860_1772.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281566.
    KOi K00627.
    OMAi VESCIIT.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci CAULONA1000:CCNA_01803-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
      Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
      J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1000 / CB15NImported.

    Entry informationi

    Entry nameiB8GW76_CAUCN
    AccessioniPrimary (citable) accession number: B8GW76
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3