SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B8GW76

- B8GW76_CAUCN

UniProt

B8GW76 - B8GW76_CAUCN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
CCNA_01803
Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_01803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:CCNA_01803Imported
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)Imported
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001364: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_1729.

Structurei

3D structure databases

ProteinModelPortaliB8GW76.
SMRiB8GW76. Positions 5-68, 197-428.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiVESCIIT.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GW76-1 [UniParc]FASTAAdd to Basket

« Hide

MSIDILMPAL SPTMEEGTLA KWHVKVGDTV KAGDVIAEIE TDKATMEVEA    50
VDEGVVEAIL VPAGTENVKV NALIAKLAGE GDSPAPAPKV EAPKAAAAAP 100
VPAAAPAPAV PAPAAPVAAD GSRVLASPLA RRLASAAGLD LKALKGTGPH 150
GRVVKSDVEA AKSGAPAAKA APASAPAAVA PTAAAPRQIQ SLEQMGIPAG 200
SYDLVPLDGM RKTIARRMTE SFRDVPHFPL TIDLEIDALL AARAKINSLL 250
EKQGVKVSVN DIVIKAAAVA LKQVPEANAS YTPEGIAMHH HADIAVAVAV 300
DGGLITPIIR KAETKGLAQI SAEMKDLAQR AKDKKLKPEE FQGGTFSISN 350
LGMFGIKSFA SIINEPQGAI MSVGAGEQRP VVKNGEIKVA TVMTVTLTCD 400
HRVVDGSVGA KFLAAFRPLI EEPLTLIV 428
Length:428
Mass (Da):44,011
Last modified:March 3, 2009 - v1
Checksum:iA8234BA3B8D6B1B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001340 Genomic DNA. Translation: ACL95268.1.
RefSeqiWP_010919597.1. NC_011916.1.
YP_002517176.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL95268; ACL95268; CCNA_01803.
GeneIDi7331269.
KEGGiccs:CCNA_01803.
PATRICi21308157. VBICauCre52860_1772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001340 Genomic DNA. Translation: ACL95268.1 .
RefSeqi WP_010919597.1. NC_011916.1.
YP_002517176.1. NC_011916.1.

3D structure databases

ProteinModelPortali B8GW76.
SMRi B8GW76. Positions 5-68, 197-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190650.CC_1729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL95268 ; ACL95268 ; CCNA_01803 .
GeneIDi 7331269.
KEGGi ccs:CCNA_01803.
PATRICi 21308157. VBICauCre52860_1772.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281566.
KOi K00627.
OMAi VESCIIT.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci CAULONA1000:CCNA_01803-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15N.

Entry informationi

Entry nameiB8GW76_CAUCN
AccessioniPrimary (citable) accession number: B8GW76
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi