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B8GW41 (DCUP_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:CCNA_03879
OrganismCaulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]
Taxonomic identifier565050 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen III to yield coproporphyrinogen III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm Probable HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Sequence caution

The sequence ACL97344.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000378316

Regions

Region32 – 365Substrate binding By similarity

Sites

Binding site511Substrate By similarity
Binding site821Substrate By similarity
Binding site1571Substrate By similarity
Binding site2111Substrate By similarity
Binding site3261Substrate By similarity
Site821Transition state stabilizer By similarity

Experimental info

Sequence conflict222 – 2232DR → EP in AAA64267. Ref.2

Sequences

Sequence LengthMass (Da)Tools
B8GW41 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: E33D7A2C98765EE8

FASTA35137,944
        10         20         30         40         50         60 
MTSSSPILKQ TPKFLSALEG QSHANPPVWF MRQAGRYLPE YRAVRATAPD FISFCFDPEK 

        70         80         90        100        110        120 
AAEVTLQPMR RFPFDASIVF ADILLIPGAL GQKVWFEAGE GPKLGDMPSV ESMAEKAGEA 

       130        140        150        160        170        180 
GKALSLVGET LTRVRSALDP DKALIGFAGA PWTVATYMIE KGSSDRSGAR TFAYQNPETL 

       190        200        210        220        230        240 
DALIQVLVDA TIDYLAMQVD AGAQALKLFE SWAEGLSEPL FDRLVTQPHI RIIEGLRARG 

       250        260        270        280        290        300 
VTVPIIGFPR GAGTLVEDYA ARTPVQGVAL DTSASAKLGQ TIQKTKTIQG ALDPLLLRAG 

       310        320        330        340        350 
GDALLKRVDE MLEQWNQGPY IFNLGHGILP DTPIAHVEAV LERVTGQKVG Q

« Hide

References

« Hide 'large scale' references
[1]"The genetic basis of laboratory adaptation in Caulobacter crescentus."
Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
J. Bacteriol. 192:3678-3688(2010) [PubMed: 20472802] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1000 / CB15N.
[2]Marczynski G.T.
Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001340 Genomic DNA. Translation: ACL97344.1. Different initiation.
U13664 Genomic DNA. Translation: AAA64267.1.
PIRI40672.

3D structure databases

ProteinModelPortalB8GW41.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8GW41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus CCNA_03879 in contig CP001340_GR.
KEGGccs:CCNA_03879.
PATRIC21312247. VBICauCre52860_3784.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBB8GW41.
ProtClustDBCLSK891699.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CAUCN
AccessionPrimary (citable) accession number: B8GW41
Secondary accession number(s): Q59269
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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