B8GVX4 (AHPD_CAUCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	CCNA_03812

Organism

Caulobacter crescentus (strain NA1000 / CB15N) [Complete proteome] [HAMAP]

Taxonomic identifier

565050 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_1000187333
Sites
	Active site	132	1	Proton donor By similarity
	Active site	135	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	132 ↔ 135		Alternate By similarity
	Disulfide bond	135		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8GVX4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: D9A0D5D8A561DFF8	FASTA	183	19,117
	10 20 30 40 50 60 MSIEALRARL PDYAHDLGTN LALLVDDPAL DPEARWGCFV ASACAVGEPQ TLRAIDAAAT 70 80 90 100 110 120 AAGLTAEANR AARKAAAMMA MTNVYFRAVH LMEGAAYQAL PCRLRLNRLA HAGARGVTYD 130 140 150 160 170 180 LSCVAVSAIN GCGACLDSHE ADLRGRGVEP TQIQAALRIA AVVSAVARTL AAEAALHPQN LEI

References

[1]

"The genetic basis of laboratory adaptation in Caulobacter crescentus." Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S. J. Bacteriol. 192:3678-3688(2010) [PubMed: 20472802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NA1000 / CB15N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001340 Genomic DNA. Translation: ACL97277.1.
RefSeq	YP_002519185.1. NC_011916.1.
3D structure databases
ProteinModelPortal	B8GVX4.
ModBase	Search...
Protein-protein interaction databases
STRING	B8GVX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7332010.
GenomeReviews	Gene locus CCNA_03812 in contig CP001340_GR.
KEGG	ccs:CCNA_03812.
PATRIC	21312111. VBICauCre52860_3716.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RAGLRMN.
ProtClustDB	CLSK2461481.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_CAUCN

Accession

Primary (citable) accession number: B8GVX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program