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Protein

Aconitate hydratase

Gene

acnA

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.UniRule annotation

Catalytic activityi

Citrate = isocitrate.UniRule annotation

Cofactori

Note: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. aconitate hydratase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_03781-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydrataseUniRule annotation (EC:4.2.1.3UniRule annotation)
Short name:
AconitaseUniRule annotation
Gene namesi
Name:acnAImported
Ordered Locus Names:CCNA_03781Imported
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)Imported
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001364 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi190650.CC_3667.

Structurei

3D structure databases

ProteinModelPortaliB8GVU3.
SMRiB8GVU3. Positions 39-893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1048.
HOGENOMiHOG000025704.
KOiK01681.
OMAiEHVENLA.
OrthoDBiEOG67DPHM.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015934. Aconitase/AcnD.
IPR006249. Aconitase/Fe_reg_2.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GVU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVDSLKAR RELKVGKQSY VYYSLRAAEE AGLADVSSLP VSMKVLLENL
60 70 80 90 100
LRNEDGVSVN EDDLKAVAAW LNNKGSVEHE ISFRPARVLM QDFTGVPAVV
110 120 130 140 150
DLAAMRDAMV ALGADPAKIN PLNPVDLVID HSVMVDNFGN PKAYDDNVKR
160 170 180 190 200
EYERNIERYR FLRWGSSAFN NFRVVPPGTG ICHQVNLEYL AQTVWTNTVD
210 220 230 240 250
GAEVAYPDTV VGTDSHTTMV NGLAVLGWGV GGIEAEAAML GQPIPMLIPE
260 270 280 290 300
VIGFKLTGAM PEGATATDLV LTVTQMLRKK GVVGKFVEFY GDALANLTLE
310 320 330 340 350
DQATIANMAP EYGATCGFFP ISAATIAYLK GTGRAAERVA LVEAYAKEQG
360 370 380 390 400
LWWEPGVAEP TFTDTLELDL STVLPSLAGP KRPQDRVLLS DAAAKFAESL
410 420 430 440 450
AGEFGKAENP ELRAPVEGED FDVGHGDVVI AAITSCTNTS NPSVLIAAGL
460 470 480 490 500
LAKNAVAKGL KAKPWVKTSL APGSQVVTDY LAKAGLTKHL DALGFNLVGY
510 520 530 540 550
GCTTCIGNSG PLPEAISKTI NDNDLVACSV LSGNRNFEGR VNPDVRANYL
560 570 580 590 600
ASPPLVVAYA LAGSLKIDLA TQPIGQDKKG NDVFLKDIWP SNEDIAALQR
610 620 630 640 650
KAINEKMFAT RYGDVFKGDK NWQGIKVTGG QTYAWEADST YVQNPPYFPN
660 670 680 690 700
MSMTPAPVTD IVEARILAVF GDSITTDHIS PAGSIKASSP AGKFLIDNGV
710 720 730 740 750
EPVDFNGYGA RRGNHQVMMR GTFANIRIRN RITPDIEGGV TKHFPTGEVM
760 770 780 790 800
SIYDAAMKYQ EEGRPAVVFG GKEYGTGSSR DWAAKGTKLL GVRAVICESF
810 820 830 840 850
ERIHRSNLVG MGVLPLQFVQ DGWQKLELTG EEIVSIRGLT DLAPRKQLIV
860 870 880 890
ELYRPTDGRI ARFPVRCRID TPTELEYFKN GGVLNYVLRN LAKAD
Length:895
Mass (Da):96,690
Last modified:March 3, 2009 - v1
Checksum:i5AF77F3A802C75E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL97246.1.
RefSeqiWP_010921494.1. NC_011916.1.
YP_002519154.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL97246; ACL97246; CCNA_03781.
GeneIDi7331979.
KEGGiccs:CCNA_03781.
PATRICi21312049. VBICauCre52860_3685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL97246.1.
RefSeqiWP_010921494.1. NC_011916.1.
YP_002519154.1. NC_011916.1.

3D structure databases

ProteinModelPortaliB8GVU3.
SMRiB8GVU3. Positions 39-893.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190650.CC_3667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL97246; ACL97246; CCNA_03781.
GeneIDi7331979.
KEGGiccs:CCNA_03781.
PATRICi21312049. VBICauCre52860_3685.

Phylogenomic databases

eggNOGiCOG1048.
HOGENOMiHOG000025704.
KOiK01681.
OMAiEHVENLA.
OrthoDBiEOG67DPHM.

Enzyme and pathway databases

BioCyciCAULONA1000:CCNA_03781-MONOMER.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015934. Aconitase/AcnD.
IPR006249. Aconitase/Fe_reg_2.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genetic basis of laboratory adaptation in Caulobacter crescentus."
    Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V., Walunas T.L., Crosson S.
    J. Bacteriol. 192:3678-3688(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1000 / CB15NImported.

Entry informationi

Entry nameiB8GVU3_CAUCN
AccessioniPrimary (citable) accession number: B8GVU3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 29, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.