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Protein

Malate dehydrogenase

Gene

mdh

Organism
Caulobacter crescentus (strain NA1000 / CB15N)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:CCNA_03770
OrganismiCaulobacter crescentus (strain NA1000 / CB15N)
Taxonomic identifieri565050 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001364 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916451 – 320Malate dehydrogenaseAdd BLAST320

Structurei

3D structure databases

ProteinModelPortaliB8GVT2.
SMRiB8GVT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GVT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAKIALIG AGMIGGTLAH IAAREELGDV ILFDIAEGTP QGKALDIAEA
60 70 80 90 100
SAVFGKDVAL KGANDYADIA GADVCIVTAG VPRKPGMSRD DLLGINLKVM
110 120 130 140 150
KAVGEGIKAH APNAFVICIT NPLDAMVWAL QQFSGLPKEK VIGMAGVLDS
160 170 180 190 200
ARFAYFLAEA TGVSVEDIHA WTLGGHGDDM VPMVRHSTVG GLPLPELVKQ
210 220 230 240 250
GWLSQDKLDA IVERTRKGGG EIVALLKTGS AFYAPAESAI AMATSYLKDK
260 270 280 290 300
KRVLPCATYL TGQYGLNDLY VGVPVVIGAG GAEKIVEFET NDDEKAMFAK
310 320
SVESVKGLME ACKAIDSSLV
Length:320
Mass (Da):33,489
Last modified:March 3, 2009 - v1
Checksum:iFE729CE1B66AE429
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001340 Genomic DNA. Translation: ACL97235.1.
RefSeqiWP_010921482.1. NC_011916.1.
YP_002519143.1. NC_011916.1.

Genome annotation databases

EnsemblBacteriaiACL97235; ACL97235; CCNA_03770.
GeneIDi7331966.
KEGGiccs:CCNA_03770.
PATRICifig|565050.3.peg.3674.

Similar proteinsi

Entry informationi

Entry nameiMDH_CAUCN
AccessioniPrimary (citable) accession number: B8GVT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families