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B8GV13

- SYL_THISH

UniProt

B8GV13 - SYL_THISH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-2313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Tgr7_2279
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Leucine--tRNA ligasePRO_1000199231Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_2279.

Structurei

3D structure databases

ProteinModelPortaliB8GV13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GV13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEHYEPDAL ERQAQTWWDE HQTFRAREDA PGEPFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMQG RNVLQPMGWD AFGLPAENAA IKHLVPPAKW
110 120 130 140 150
TYENIAYMRG QLQRLGFGYD WDRELATCRP EYYRWEQWLF TRLVKKGLAY
160 170 180 190 200
KKTAMVNWDP VDQTVLANEQ VIDGKGWRSG APVERREIPQ WFLRITDYAE
210 220 230 240 250
ELLKGLDGLE GWPEQVRTMQ RNWIGRSEGV ELEFEVPGEA PLTVYTTRPD
260 270 280 290 300
TLMGVSYVGV APEHPLAARA AEGDGKLAAF IEACRHTKVS EADMATLEKK
310 320 330 340 350
GMDTGLKAVH PVTGEPVPVW VANFVLMEYG TGAVMAVPAH DQRDWEFARQ
360 370 380 390 400
YGLPVRQVIL PAEEGVAVDL DQAAFTDKGV LIESAQFNGL SSAQAFDAIA
410 420 430 440 450
DFLEKQHKGR RRVNYRLRDW GVSRQRYWGC PIPIINCPDC GPVPVPEEQL
460 470 480 490 500
PVVLPEDVAF DGVGSPIKRM PEFIDTTCPE CGGKAERETD TFDTFFESSW
510 520 530 540 550
YYARYTCKDA DGAMLDERAR HWLPVDQYIG GIEHAVLHLL YARFFHKLMR
560 570 580 590 600
DEGLVDGDEP FTRLLTQGMV LKDGAKMSKS KGNTVDPEAL IERYGADTVR
610 620 630 640 650
LFMMFAAPPE LSLEWSDSGV EGAYRFLKRL WKQVHDHVQG GAAPALDKAA
660 670 680 690 700
LNADQQALRR KLHQTLAKVS DDIGRRTTFN TAIAACMELM NELGRFEDKS
710 720 730 740 750
GQGRAVMQEA LETTVLMLSP IVPHIAHALW SELGREGAAV DQPWPVVDES
760 770 780 790 800
ALESDTVELV VQVNGKLRAQ IQVPAAAARA AIEEAALADE NVQRHIEGKT
810
VVKMVVVPGR LVNVVVK
Length:817
Mass (Da):91,879
Last modified:March 3, 2009 - v1
Checksum:i4D8F3A4160C9299D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL73359.1.
RefSeqiYP_002514346.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL73359; ACL73359; Tgr7_2279.
GeneIDi7317528.
KEGGitgr:Tgr7_2279.
PATRICi23964084. VBIThiSp19295_2273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL73359.1 .
RefSeqi YP_002514346.1. NC_011901.1.

3D structure databases

ProteinModelPortali B8GV13.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_2279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL73359 ; ACL73359 ; Tgr7_2279 .
GeneIDi 7317528.
KEGGi tgr:Tgr7_2279.
PATRICi 23964084. VBIThiSp19295_2273.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-2313-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7.

Entry informationi

Entry nameiSYL_THISH
AccessioniPrimary (citable) accession number: B8GV13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3