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B8GV13

- SYL_THISH

UniProt

B8GV13 - SYL_THISH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSUL396588:GH5B-2313-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tgr7_2279
    OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
    Taxonomic identifieri396588 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
    ProteomesiUP000002383: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817Leucine--tRNA ligasePRO_1000199231Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi396588.Tgr7_2279.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GV13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8GV13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEHYEPDAL ERQAQTWWDE HQTFRAREDA PGEPFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMQG RNVLQPMGWD AFGLPAENAA IKHLVPPAKW 100
    TYENIAYMRG QLQRLGFGYD WDRELATCRP EYYRWEQWLF TRLVKKGLAY 150
    KKTAMVNWDP VDQTVLANEQ VIDGKGWRSG APVERREIPQ WFLRITDYAE 200
    ELLKGLDGLE GWPEQVRTMQ RNWIGRSEGV ELEFEVPGEA PLTVYTTRPD 250
    TLMGVSYVGV APEHPLAARA AEGDGKLAAF IEACRHTKVS EADMATLEKK 300
    GMDTGLKAVH PVTGEPVPVW VANFVLMEYG TGAVMAVPAH DQRDWEFARQ 350
    YGLPVRQVIL PAEEGVAVDL DQAAFTDKGV LIESAQFNGL SSAQAFDAIA 400
    DFLEKQHKGR RRVNYRLRDW GVSRQRYWGC PIPIINCPDC GPVPVPEEQL 450
    PVVLPEDVAF DGVGSPIKRM PEFIDTTCPE CGGKAERETD TFDTFFESSW 500
    YYARYTCKDA DGAMLDERAR HWLPVDQYIG GIEHAVLHLL YARFFHKLMR 550
    DEGLVDGDEP FTRLLTQGMV LKDGAKMSKS KGNTVDPEAL IERYGADTVR 600
    LFMMFAAPPE LSLEWSDSGV EGAYRFLKRL WKQVHDHVQG GAAPALDKAA 650
    LNADQQALRR KLHQTLAKVS DDIGRRTTFN TAIAACMELM NELGRFEDKS 700
    GQGRAVMQEA LETTVLMLSP IVPHIAHALW SELGREGAAV DQPWPVVDES 750
    ALESDTVELV VQVNGKLRAQ IQVPAAAARA AIEEAALADE NVQRHIEGKT 800
    VVKMVVVPGR LVNVVVK 817
    Length:817
    Mass (Da):91,879
    Last modified:March 3, 2009 - v1
    Checksum:i4D8F3A4160C9299D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001339 Genomic DNA. Translation: ACL73359.1.
    RefSeqiYP_002514346.1. NC_011901.1.

    Genome annotation databases

    EnsemblBacteriaiACL73359; ACL73359; Tgr7_2279.
    GeneIDi7317528.
    KEGGitgr:Tgr7_2279.
    PATRICi23964084. VBIThiSp19295_2273.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001339 Genomic DNA. Translation: ACL73359.1 .
    RefSeqi YP_002514346.1. NC_011901.1.

    3D structure databases

    ProteinModelPortali B8GV13.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 396588.Tgr7_2279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL73359 ; ACL73359 ; Tgr7_2279 .
    GeneIDi 7317528.
    KEGGi tgr:Tgr7_2279.
    PATRICi 23964084. VBIThiSp19295_2273.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TSUL396588:GH5B-2313-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HL-EbGR7.

    Entry informationi

    Entry nameiSYL_THISH
    AccessioniPrimary (citable) accession number: B8GV13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3