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B8GV10 (B8GV10_THISH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412
Ordered Locus Names:Tgr7_2276
OrganismThioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]
Taxonomic identifier396588 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis HAMAP MF_00412
   Cellular componentCytoplasm HAMAP MF_00412
   LigandNADP HAMAP MF_00412
   Molecular functionOxidoreductase HAMAP MF_00412
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B8GV10 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 6EC67D0F24971847

FASTA42745,754
        10         20         30         40         50         60 
MNAVVENMTG EIERQMQEMG RRARAASRAL ARAETGAKNA ALMAMASVIE ARAEALMAEN 

        70         80         90        100        110        120 
RKDLEAGEQN GLDAALLDRL AFTPERIAVM AEGLRQIATL PDPVGAISDL NYRPSGIQVG 

       130        140        150        160        170        180 
RMRVPLGVIG IIYESRPNVT VDAAGLCLKS GNACILRGGS EAFHSNRALA ECIRAGLEQA 

       190        200        210        220        230        240 
GLPVDAVQVV ATTDRAAVGA LLRMKDFVDV IVPRGGKGLI ARVSEESLIP VIKHLDGVCH 

       250        260        270        280        290        300 
VYLDDGADPD KALKVSVNAK THRYGTCNTM ETLLVSRAVA EQMLPALGQA FEEKGVELRG 

       310        320        330        340        350        360 
CAATRAILPG IKEATEQDWF EEYLAPVLAV RVVDGLDAAI EHINTYGSHH TDSIITEDYT 

       370        380        390        400        410        420 
RARRFLREVD SSSVMVNAST RFADGFEYGL GAEIGISTDK LHARGPVGLE GLTTLKYVVL 


GDGHVRS

« Hide

References

[1]"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
Stand. Genomic Sci. 4:23-35(2011) [PubMed: 21475584] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HL-EbGR7 EMBL ACL73356.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001339 Genomic DNA. Translation: ACL73356.1.
RefSeqYP_002514343.1. NC_011901.1.

3D structure databases

ProteinModelPortalB8GV10.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8GV10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7317525.
GenomeReviewsGene locus Tgr7_2276 in contig CP001339_GR.
KEGGtgr:Tgr7_2276.
PATRIC23964078. VBIThiSp19295_2270.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG318080.
OMAYGICGAM.
ProtClustDBCLSK2807103.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GV10_THISH
AccessionPrimary (citable) accession number: B8GV10
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info