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B8GUU7 (B8GUU7_THISH) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:Tgr7_0360
OrganismThioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP] EMBL ACL71458.1
Taxonomic identifier396588 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio ›

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 316208ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding135 – 19662ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2861Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2881Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
B8GUU7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: D6C8E560D115E51D

FASTA43045,506
        10         20         30         40         50         60 
MKVLVIGGGG REHALAWKLA QSPRVQTVFV APGNAGTALE PRCLNVEVNL SDIPALVHFA 

        70         80         90        100        110        120 
QSQGVDLTVV GPEAPLVAGV VDAFRAAGLR IFGPSSKAAQ LEGSKAFSKD FLARHAIPTA 

       130        140        150        160        170        180 
AYANFTDLDA ALAYIRERGA PIVVKADGLA AGKGVILAQT VAEAEAAVRD MLAGNAFGEA 

       190        200        210        220        230        240 
GHRVVVEEFL TGEEASFICM VDGEHILPMA SSQDHKARDD GDKGPNTGGM GAYSPAPVVT 

       250        260        270        280        290        300 
PEIHARIMRE VMEPTVRGMA AEGNPYTGFL YAGVMIAPDG TPKVLEFNCR FGDPETQPIM 

       310        320        330        340        350        360 
MRLRSDLVDL LEAALDARLD QVEADWDPRA SLGVVLAAGG YPNDYRKGDV IIGLPEQDAP 

       370        380        390        400        410        420 
DAKVFHAGTL QQDGAVVTNG GRVLCVVGLG ETVAEAQKRA YALSDRIHWD GVYCRRDIGY 

       430 
RAVAREQGRA

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References

[1]"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HL-EbGR7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001339 Genomic DNA. Translation: ACL71458.1.
RefSeqYP_002512445.1. NC_011901.1.

3D structure databases

ProteinModelPortalB8GUU7.
ModBaseSearch...

Protein-protein interaction databases

STRING396588.Tgr7_0360.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL71458; ACL71458; Tgr7_0360.
GeneID7316499.
KEGGtgr:Tgr7_0360.
PATRIC23960214. VBIThiSp19295_0367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
KOK01945.
OMAMGAYTPL.

Enzyme and pathway databases

UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GUU7_THISH
AccessionPrimary (citable) accession number: B8GUU7
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info