B8GUR7 (UPPP_THISH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	Tgr7_0330

Organism

Thioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]

Taxonomic identifier

396588 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio › Thioalkalivibrio sulfidophilus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000148835
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	188 – 208	21	Helical; Potential
	Transmembrane	219 – 239	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B8GUR7 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 58B1F3FAFF40DB24	FASTA	266	28,755
	10 20 30 40 50 60 MDLFQTLVLA LVQGLTEFLP ISSAAHLILV PELTDWDDQG LAFDVATHVG SLAAVVIYFR 70 80 90 100 110 120 HELRRMTAEW LGSLAGRGLT PDAKLAWAVG LGTIPAGLAG LLFHDIIATH LRSAQVIAMA 130 140 150 160 170 180 TIGFAVLLLF ADVSGKRTRD EHSITWKDVL VIGVAQALAL IPGTSRSGIT ITAALLMGFT 190 200 210 220 230 240 RQAAARYSFL LSIPIIALAG GFEILGLVKE PEENIQWGMI VLGALVAGVS AYLCIHYFLK 250 260 LLAKMTMLPF VIYRLVLGAF LLFLFW

References

[1]

"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7." Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C. Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HL-EbGR7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001339 Genomic DNA. Translation: ACL71428.1.
RefSeq	YP_002512415.1. NC_011901.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	396588.Tgr7_0330.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL71428; ACL71428; Tgr7_0330.
GeneID	7316306.
KEGG	tgr:Tgr7_0330.
PATRIC	23960152. VBIThiSp19295_0336.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
KO	K06153.
OMA	FRFAVWI.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_THISH

Accession

Primary (citable) accession number: B8GUR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program