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B8GSK6

- B8GSK6_THISH

UniProt

B8GSK6 - B8GSK6_THISH

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Protein

Thymidylate kinase

Gene

tmk

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-1857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Tgr7_1829Imported
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)Imported
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_1829.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
KOiK00943.
OMAiEPGGCPI.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GSK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQPTTARGR FITLEGAEGV GKSTQIQALQ AFLESRGVPL LVTREPGGTP
60 70 80 90 100
LAERIRELLL SRDHPPMHPD TELLLMFAAR AEHLRTRILP ALEAGTWVLC
110 120 130 140 150
DRFTDATYAY QGGGRGLDPA RIAVLEDWVQ GPVRPDLTLL LDVDVRTGLA
160 170 180 190 200
RARGRGEADR FEQEAMDFFE RVREAYLARA RAEPSRYRII DAGQSLEAVT
210
RDLQAALVSL LQANGVTP
Length:218
Mass (Da):24,112
Last modified:March 3, 2009 - v1
Checksum:iCBE3EC7830BEE735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001339 Genomic DNA. Translation: ACL72910.1.
RefSeqiYP_002513897.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL72910; ACL72910; Tgr7_1829.
GeneIDi7317639.
KEGGitgr:Tgr7_1829.
PATRICi23963168. VBIThiSp19295_1821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001339 Genomic DNA. Translation: ACL72910.1 .
RefSeqi YP_002513897.1. NC_011901.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_1829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL72910 ; ACL72910 ; Tgr7_1829 .
GeneIDi 7317639.
KEGGi tgr:Tgr7_1829.
PATRICi 23963168. VBIThiSp19295_1821.

Phylogenomic databases

eggNOGi COG0125.
KOi K00943.
OMAi EPGGCPI.
OrthoDBi EOG64JFSH.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-1857-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
    Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
    Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7Imported.

Entry informationi

Entry nameiB8GSK6_THISH
AccessioniPrimary (citable) accession number: B8GSK6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3