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Protein

Thymidylate kinase

Gene

tmk

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processNucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Tgr7_1829Imported
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)Imported
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
Proteomesi
  • UP000002383 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_1829.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
KOiK00943.
OMAiFLYTADH.
OrthoDBiPOG091H02B9.

Family and domain databases

HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
PANTHERiPTHR10344:SF4. PTHR10344:SF4. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GSK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQPTTARGR FITLEGAEGV GKSTQIQALQ AFLESRGVPL LVTREPGGTP
60 70 80 90 100
LAERIRELLL SRDHPPMHPD TELLLMFAAR AEHLRTRILP ALEAGTWVLC
110 120 130 140 150
DRFTDATYAY QGGGRGLDPA RIAVLEDWVQ GPVRPDLTLL LDVDVRTGLA
160 170 180 190 200
RARGRGEADR FEQEAMDFFE RVREAYLARA RAEPSRYRII DAGQSLEAVT
210
RDLQAALVSL LQANGVTP
Length:218
Mass (Da):24,112
Last modified:March 3, 2009 - v1
Checksum:iCBE3EC7830BEE735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001339 Genomic DNA. Translation: ACL72910.1.
RefSeqiWP_012638392.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL72910; ACL72910; Tgr7_1829.
KEGGitgr:Tgr7_1829.

Similar proteinsi

Entry informationi

Entry nameiB8GSK6_THISH
AccessioniPrimary (citable) accession number: B8GSK6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported