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B8GSK6

- B8GSK6_THISH

UniProt

B8GSK6 - B8GSK6_THISH

Protein

Thymidylate kinase

Gene

tmk

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 238ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTSUL396588:GH5B-1857-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
    Alternative name(s):
    dTMP kinaseUniRule annotation
    Gene namesi
    Name:tmkUniRule annotation
    Ordered Locus Names:Tgr7_1829Imported
    OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)Imported
    Taxonomic identifieri396588 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
    ProteomesiUP000002383: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi396588.Tgr7_1829.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0125.
    KOiK00943.
    OMAiEPGGCPI.
    OrthoDBiEOG64JFSH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8GSK6-1 [UniParc]FASTAAdd to Basket

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    MNQPTTARGR FITLEGAEGV GKSTQIQALQ AFLESRGVPL LVTREPGGTP    50
    LAERIRELLL SRDHPPMHPD TELLLMFAAR AEHLRTRILP ALEAGTWVLC 100
    DRFTDATYAY QGGGRGLDPA RIAVLEDWVQ GPVRPDLTLL LDVDVRTGLA 150
    RARGRGEADR FEQEAMDFFE RVREAYLARA RAEPSRYRII DAGQSLEAVT 200
    RDLQAALVSL LQANGVTP 218
    Length:218
    Mass (Da):24,112
    Last modified:March 3, 2009 - v1
    Checksum:iCBE3EC7830BEE735
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001339 Genomic DNA. Translation: ACL72910.1.
    RefSeqiYP_002513897.1. NC_011901.1.

    Genome annotation databases

    EnsemblBacteriaiACL72910; ACL72910; Tgr7_1829.
    GeneIDi7317639.
    KEGGitgr:Tgr7_1829.
    PATRICi23963168. VBIThiSp19295_1821.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001339 Genomic DNA. Translation: ACL72910.1 .
    RefSeqi YP_002513897.1. NC_011901.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 396588.Tgr7_1829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL72910 ; ACL72910 ; Tgr7_1829 .
    GeneIDi 7317639.
    KEGGi tgr:Tgr7_1829.
    PATRICi 23963168. VBIThiSp19295_1821.

    Phylogenomic databases

    eggNOGi COG0125.
    KOi K00943.
    OMAi EPGGCPI.
    OrthoDBi EOG64JFSH.

    Enzyme and pathway databases

    BioCyci TSUL396588:GH5B-1857-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
      Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
      Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HL-EbGR7Imported.

    Entry informationi

    Entry nameiB8GSK6_THISH
    AccessioniPrimary (citable) accession number: B8GSK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3