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B8GSK6

- B8GSK6_THISH

UniProt

B8GSK6 - B8GSK6_THISH

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Protein

Thymidylate kinase

Gene
tmk, Tgr7_1829
Organism
Thioalkalivibrio sp. (strain HL-EbGR7)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotationSAAS annotations

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Nucleotide biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-1857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Tgr7_1829Imported
OrganismiThioalkalivibrio sp. (strain HL-EbGR7)Imported
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_1829.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
KOiK00943.
OMAiEPGGCPI.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GSK6-1 [UniParc]FASTAAdd to Basket

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MNQPTTARGR FITLEGAEGV GKSTQIQALQ AFLESRGVPL LVTREPGGTP    50
LAERIRELLL SRDHPPMHPD TELLLMFAAR AEHLRTRILP ALEAGTWVLC 100
DRFTDATYAY QGGGRGLDPA RIAVLEDWVQ GPVRPDLTLL LDVDVRTGLA 150
RARGRGEADR FEQEAMDFFE RVREAYLARA RAEPSRYRII DAGQSLEAVT 200
RDLQAALVSL LQANGVTP 218
Length:218
Mass (Da):24,112
Last modified:March 3, 2009 - v1
Checksum:iCBE3EC7830BEE735
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL72910.1.
RefSeqiYP_002513897.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL72910; ACL72910; Tgr7_1829.
GeneIDi7317639.
KEGGitgr:Tgr7_1829.
PATRICi23963168. VBIThiSp19295_1821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL72910.1 .
RefSeqi YP_002513897.1. NC_011901.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_1829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL72910 ; ACL72910 ; Tgr7_1829 .
GeneIDi 7317639.
KEGGi tgr:Tgr7_1829.
PATRICi 23963168. VBIThiSp19295_1821.

Phylogenomic databases

eggNOGi COG0125.
KOi K00943.
OMAi EPGGCPI.
OrthoDBi EOG64JFSH.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-1857-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
    Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
    Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7Imported.

Entry informationi

Entry nameiB8GSK6_THISH
AccessioniPrimary (citable) accession number: B8GSK6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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